伴有和不伴有先兆的偏头痛患者血小板及血浆中谷氨酸和谷氨酰胺的水平

Platelet and plasma levels of glutamate and glutamine in migraine with and without aura.

作者信息

Cananzi A R, D'Andrea G, Perini F, Zamberlan F, Welch K M

机构信息

Department of Neurology, San Bortolo Hospital, Vincenza, Italy.

出版信息

Cephalalgia. 1995 Apr;15(2):132-5. doi: 10.1046/j.1468-2982.1995.015002132.x.

DOI:10.1046/j.1468-2982.1995.015002132.x

PMID:7641248

Abstract

We evaluated plasma and platelet glutamate and glutamine levels in migraine with and without aura during headache-free periods and compared the results with those of normal controls. The plasma and platelet levels of glutamine in migraine with and without aura were normal. Migraine without aura patients had higher glutamate levels in plasma, and normal platelet levels. In migraine with aura patients, glutamate levels were high in platelets, but not in plasma. This suggests different profiles of excitatory amino acid metabolism in migraine with and without aura.

摘要

我们评估了有无先兆偏头痛患者在无头痛期的血浆和血小板谷氨酸及谷氨酰胺水平，并将结果与正常对照组进行比较。有无先兆偏头痛患者的血浆和血小板谷氨酰胺水平均正常。无先兆偏头痛患者血浆中的谷氨酸水平较高，血小板水平正常。有先兆偏头痛患者的血小板中谷氨酸水平较高，但血浆中不高。这表明有无先兆偏头痛患者的兴奋性氨基酸代谢情况不同。