Alam Z, Coombes N, Waring R H, Williams A C, Steventon G B
School of Biochemistry, The University of Birmingham, Edgbaston, UK.
J Neurol Sci. 1998;156(1):102-6. doi: 10.1016/s0022-510x(98)00023-9.
Plasma amino acids were analysed in patients with migraine with (9) and without (80) aura, in patients with tension headache (14) and in controls (62). The neuroexcitatory amino acids glutamic acid, glutamine, glycine, cysteic acid and homocysteic acid were elevated in migraine patients while total thiols (cysteine/cystine) were reduced. Patients with tension headache had values which were similar to those of controls. Tryptophan was elevated in migraine patients without aura only. Studies on two patients showed that the raised resting excitatory amino acid levels became still further elevated during a migraine attack. These results show that high concentrations of neurotransmitter amino acids occur normally in migraine patients and suggest that this profile may be a contributory factor in migraine attacks. Tension headache, however, has different biochemical parameters.
对伴有先兆（9例）和不伴有先兆（80例）的偏头痛患者、紧张性头痛患者（14例）及对照组（62例）的血浆氨基酸进行了分析。偏头痛患者的神经兴奋性氨基酸，如谷氨酸、谷氨酰胺、甘氨酸、半胱氨酸和高半胱氨酸水平升高，而总硫醇（半胱氨酸/胱氨酸）水平降低。紧张性头痛患者的各项数值与对照组相似。仅无先兆偏头痛患者的色氨酸水平升高。对两名患者的研究表明，在偏头痛发作期间，静息时升高的兴奋性氨基酸水平会进一步升高。这些结果表明，偏头痛患者体内通常存在高浓度的神经递质氨基酸，提示这种情况可能是偏头痛发作的一个促成因素。然而，紧张性头痛具有不同的生化参数。
