D'Andrea Giovanni, Granella Franco, Perini Francesco, Farruggio Angelo, Leone Massimo, Bussone Gennaro
Headache Centre, Villa Margherita Hospital, Arcugnano, VI, Italy.
Headache. 2006 Apr;46(4):585-91. doi: 10.1111/j.1526-4610.2006.00407.x.
To measure plasma and platelet levels of dopamine in patients with migraine with aura, migraine without aura, and cluster headache.
Clinical, genetic, and pharmacological evidences suggest that an abnormality of dopaminergic system plays a role in migraine pathogenesis. Direct evidence of an abnormal metabolism of dopamine in migraine, however, is lacking.
Plasma and platelet levels of dopamine were measured in patients with migraine with aura or migraine without aura during headache-free periods and in patients with cluster headache during the remission and active periods, as compared with healthy control subjects, using a multichannel electrochemical high-performance liquid chromatography system.
Plasma levels of dopamine were not detectable with our methodology. Platelet levels of dopamine were higher in both types of migraine (migraine without aura = .20 +/- .17 ng/10(8) platelets; migraine with aura = .16 +/- .19 ng/10(8) platelets) than in control subjects (.10 +/- .11 ng/10(8) platelets), although in migraine with aura patients the difference was not significant. Patients with cluster headache showed the highest levels of platelet dopamine (.34 +/- .36 ng/10(8) platelets).
Our results support the hypothesis that the dopaminergic system is impaired in migraine and cluster headache and suggest that high platelet levels of dopamine may represent an abnormal biochemical phenotypic trait of these primary headaches.
测量伴有先兆偏头痛、无先兆偏头痛和丛集性头痛患者血浆及血小板中的多巴胺水平。
临床、遗传学和药理学证据表明，多巴胺能系统异常在偏头痛发病机制中起作用。然而，偏头痛中多巴胺代谢异常的直接证据尚缺乏。
使用多通道电化学高效液相色谱系统，测量伴有先兆偏头痛或无先兆偏头痛患者在头痛缓解期的血浆及血小板多巴胺水平，以及丛集性头痛患者在缓解期和发作期的血浆及血小板多巴胺水平，并与健康对照者进行比较。
用我们的方法无法检测到血浆中的多巴胺水平。两种偏头痛（无先兆偏头痛 = 0.20±0.17 ng/10⁸血小板；伴有先兆偏头痛 = 0.16±0.19 ng/10⁸血小板）患者的血小板多巴胺水平均高于对照者（0.10±0.11 ng/10⁸血小板），不过伴有先兆偏头痛患者的差异不显著。丛集性头痛患者的血小板多巴胺水平最高（0.34±0.36 ng/10⁸血小板）。
我们的结果支持多巴胺能系统在偏头痛和丛集性头痛中受损的假说，并表明血小板多巴胺水平升高可能代表这些原发性头痛的一种异常生化表型特征。
