Avanzini G
International League Against Epilepsy, Istituto Nazionale Neurologico C. Besta, Milano, Italy.
Ital J Neurol Sci. 1995 Feb-Mar;16(1-2):5-8. doi: 10.1007/BF02229068.
Animal studies have significantly contributed to our understanding of epileptogenesis and action mechanisms of antiepileptic drugs. The relevance of animal models to human epilepsies depend on how faithfully they reproduce the clinical and EEG features of human forms. In principle the definition of animal model of epilepsies should be reserved to animals presenting with recurrent seizures, either spontaneous of experimentally induced, persisting over time. Therefore acute experimental procedures designed to induce seizure and in vitro preparations should be referred to as models of seizures and models of epileptogenic mechanisms respectively rather models of epilepsies. The adequacy of a given animal model to study basic mechanisms of epilepsies and/or drug efficacy depend on the type of information that the investigator want to draw from it.
动物研究为我们理解癫痫发生机制和抗癫痫药物的作用机制做出了重大贡献。动物模型与人类癫痫的相关性取决于它们对人类癫痫临床和脑电图特征的再现程度。原则上，癫痫动物模型的定义应仅限于出现反复癫痫发作的动物，这些发作可以是自发的或实验诱导的，并且持续存在。因此，旨在诱导癫痫发作的急性实验程序和体外制备分别应称为癫痫发作模型和癫痫发生机制模型，而不是癫痫模型。特定动物模型用于研究癫痫基本机制和/或药物疗效的适用性取决于研究者希望从中获取的信息类型。
