Chrostek Maj J, Czeczótko B
Department of Toxicology Collegium Medicum, Jagiellonian University, Kraków, Poland.
Przegl Lek. 1995;52(5):249-51.
Prospective clinical studies were undertaken in 114 healthy men aged from 19 to 46 years (mean 26) occupationally exposed to CS2. The 62 men from the control group were undergoing examination in the same way before employment and after 5 years. The mean wages of the air concentration of CS2 at working posts was from 0 to 65 mg/m3. After 5 years of exposure no considerable differences were found in general medical examination with diastolic/systolic blood pressure measurement, resting ECG record and chest X ray examination. However in LAB test the lipid metabolism disturbances occurred. After 5 years the serum concentration of triglicerides and betalipoproteides of exposed workers were significantly higher than in the control group. The serum concentration of total cholesterol of both group was increased. The mentioned changes of lipid metabolism are the factors which indicate atherosclerotical changes in the man occupationally exposed to low concentration of CS2.
对114名年龄在19至46岁（平均26岁）职业性接触二硫化碳的健康男性进行了前瞻性临床研究。对照组的62名男性在就业前和5年后以相同方式接受检查。工作岗位上二硫化碳的空气浓度平均工资为0至65毫克/立方米。接触5年后，在一般体格检查中，舒张压/收缩压测量、静息心电图记录和胸部X光检查未发现明显差异。然而，在实验室检查中出现了脂质代谢紊乱。5年后，接触组工人的甘油三酯和β脂蛋白血清浓度显著高于对照组。两组的总胆固醇血清浓度均升高。上述脂质代谢变化是表明职业性接触低浓度二硫化碳的男性出现动脉粥样硬化变化的因素。
