钙释放激活电流（CRAC）在胰腺β细胞电活动胆碱能调节中的作用。
A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells.
作者信息
Bertram R, Smolen P, Sherman A, Mears D, Atwater I, Martin F, Soria B
机构信息
Mathematical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
Biophys J. 1995 Jun;68(6):2323-32. doi: 10.1016/S0006-3495(95)80414-5.
Abstract
S. Bordin and colleagues have proposed that the depolarizing effects of acetylcholine and other muscarinic agonists on pancreatic beta-cells are mediated by a calcium release-activated current (CRAC). We support this hypothesis with additional data, and present a theoretical model which accounts for most known data on muscarinic effects. Additional phenomena, such as the biphasic responses of beta-cells to changes in glucose concentration and the depolarizing effects of the sarco-endoplasmic reticulum calcium ATPase pump poison thapsigargin, are also accounted for by our model. The ability of this single hypothesis, that CRAC is present in beta-cells, to explain so many phenomena motivates a more complete characterization of this current.
摘要
S. 博尔丁及其同事提出，乙酰胆碱和其他毒蕈碱激动剂对胰腺β细胞的去极化作用是由钙释放激活电流（CRAC）介导的。我们用更多数据支持这一假设，并提出一个理论模型，该模型解释了关于毒蕈碱效应的大多数已知数据。我们的模型还解释了其他现象，如β细胞对葡萄糖浓度变化的双相反应以及肌浆网钙ATP酶泵抑制剂毒胡萝卜素的去极化作用。CRAC存在于β细胞这一单一假设能够解释如此多现象，这促使我们对这种电流进行更全面的表征。
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本文引用的文献
1
Demonstration of a novel apamin-insensitive calcium-activated K+ channel in mouse pancreatic B cells.小鼠胰腺β细胞中一种新型蜂毒明肽不敏感的钙激活钾通道的证明。
Pflugers Arch. 1993 Feb;422(5):443-8. doi: 10.1007/BF00375069.
2
Depletion of InsP3 stores activates a Ca2+ and K+ current by means of a phosphatase and a diffusible messenger.肌醇三磷酸（InsP3）储存的耗尽通过一种磷酸酶和一种可扩散信使激活钙电流和钾电流。
Nature. 1993 Aug 26;364(6440):814-8. doi: 10.1038/364814a0.
3
Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.T淋巴细胞的丝裂原调节钙电流由细胞内钙库耗竭激活。
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6295-9. doi: 10.1073/pnas.90.13.6295.
4
Effect of voltage-gated plasma membrane Ca2+ fluxes on IP3-linked Ca2+ oscillations.电压门控质膜Ca2+通量对IP3相关Ca2+振荡的影响。
Cell Calcium. 1993 May;14(5):397-410. doi: 10.1016/0143-4160(93)90044-7.
5
Voltage-dependent intracellular calcium release from mouse islets stimulated by glucose.葡萄糖刺激下小鼠胰岛中电压依赖性细胞内钙释放。
J Biol Chem. 1993 May 15;268(14):9953-6.
6
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx.细胞内钙库排空会释放一种新型小分子信使，该信使可刺激钙内流。
Nature. 1993 Aug 26;364(6440):809-14. doi: 10.1038/364809a0.
7
Oscillations of secretion driven by oscillations of cytoplasmic Ca2+ as evidences in single pancreatic islets.细胞质Ca2+振荡驱动的分泌振荡，这在单个胰岛中得到了证实。
J Biol Chem. 1993 Oct 25;268(30):22265-8.
8
Endoplasmic reticulum calcium store regulates membrane potential in mouse islet beta-cells.内质网钙库调节小鼠胰岛β细胞的膜电位。
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9
Equations for InsP3 receptor-mediated [Ca2+]i oscillations derived from a detailed kinetic model: a Hodgkin-Huxley like formalism.源自详细动力学模型的肌醇三磷酸受体介导的[Ca2+]i振荡方程：一种类似霍奇金-赫胥黎的形式主义。
J Theor Biol. 1994 Feb 21;166(4):461-73. doi: 10.1006/jtbi.1994.1041.
10
Control of cytosolic free calcium in cultured human pancreatic beta-cells occurs by external calcium-dependent and independent mechanisms.培养的人胰腺β细胞中胞质游离钙的调控通过外部钙依赖性和非依赖性机制实现。
Endocrinology. 1994 Apr;134(4):1771-81. doi: 10.1210/endo.134.4.8137742.
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