Cooksley W G, McIvor C A
Clinical Research Centre, Royal Brisbane Hospital Foundation Bancroft Centre, Queensland, Australia.
Biomed Pharmacother. 1995;49(3):117-24. doi: 10.1016/0753-3322(96)82604-7.
Liver failure caused by reactivation of hepatitis B virus (HBV) is an uncommon complication of bone marrow transplantation. Fibrosing cholestatic hepatitis is a recently described liver lesion that develops in some patients undergoing liver transplantation for chronic HBV infection. The lesion is characterised by peri portal fibrosis, ballooning degeneration of hepatocytes, prominent cholestasis and paucity of inflammation. Recent data suggests it is a cytopathic effect of the pre-core mutant form of HBV with over-expression of viral antigens. Although only one case has so far been described associated with bone marrow transplantation (BMT) it is likely that increasing use of BMT in people with chronic HBV infection will lead to further patients being recognised.
乙肝病毒（HBV）再激活所致肝衰竭是骨髓移植的一种罕见并发症。纤维性胆汁淤积性肝炎是一种最近才被描述的肝脏病变，见于一些接受肝移植治疗慢性HBV感染的患者。该病变的特征为汇管区周围纤维化、肝细胞气球样变、显著胆汁淤积以及炎症轻微。最近的数据表明，它是HBV前核心突变体形式的一种细胞病变效应，伴有病毒抗原过度表达。尽管目前仅报道了1例与骨髓移植（BMT）相关的病例，但随着慢性HBV感染患者中BMT使用的增加，可能会发现更多患者。
