Marcovina S M, Morrisett J D
Department of Medicine, University of Washington, Seattle, USA.
Curr Opin Lipidol. 1995 Jun;6(3):136-45. doi: 10.1097/00041433-199506000-00005.
An understanding of the complex structural and metabolic features of lipoprotein (a) is essential because this lipoprotein particle, with poorly recognized physiological functions, has been implicated in both thrombogenesis and atherogenesis. Studies aimed at investigating the structure-function relationship of apolipoprotein (a) have generated new useful information. In-vivo and in-vitro studies have provided insights into the synthesis, secretion, and association of apolipoprotein (a) with apolipoprotein B100 and the mechanisms regulating the lipoprotein (a) concentration in the bloodstream.
了解脂蛋白(a)复杂的结构和代谢特征至关重要，因为这种生理功能鲜为人知的脂蛋白颗粒与血栓形成和动脉粥样硬化的发生均有关联。旨在研究载脂蛋白(a)结构与功能关系的研究已产生了新的有用信息。体内和体外研究为载脂蛋白(a)的合成、分泌及其与载脂蛋白B100的结合，以及调节血液中脂蛋白(a)浓度的机制提供了深入见解。
