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1
Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan.接受环磷酰胺和白消安联合剂量的小鼠致死率降低。
Br J Cancer. 1975 Aug;32(2):193-8. doi: 10.1038/bjc.1975.149.
2
The relationship between granulocytic and erythroid repopulating ability.
Exp Hematol. 1974;2(3):131-7.
3
The effect of various cytotoxic agents on bone marrow progenitor cells as measured by diffusion chamber assays.通过扩散盒试验测定的各种细胞毒性剂对骨髓祖细胞的影响。
Br J Haematol. 1975 Jan;29(1):31-42. doi: 10.1111/j.1365-2141.1975.tb01797.x.
4
Kinetics of destruction and regeneration of the haemopoietic system after administration of busulphan and cyclophosphamide followed by bone marrow transplantation. Peripheral blood parameters.白消安和环磷酰胺给药后进行骨髓移植时造血系统的破坏与再生动力学。外周血参数。
Acta Med Pol. 1989;30(3-4):93-109.
5
The granulopoietic effect of human urinary colony stimulating factor on normal and cyclophosphamide treated mice.
Exp Hematol. 1983 Nov;11(10):1027-36.
6
Granulocyte colony-stimulating factor stimulates recovery of granulocytes in patients receiving dose-intensive chemotherapy without bone marrow transplantation.粒细胞集落刺激因子可促进接受高剂量化疗但未进行骨髓移植患者的粒细胞恢复。
J Clin Oncol. 1989 Nov;7(11):1685-92. doi: 10.1200/JCO.1989.7.11.1685.
7
Lactoferrin accelerates reconstitution of the humoral and cellular immune response during chemotherapy-induced immunosuppression and bone marrow transplant in mice.乳铁蛋白可加速小鼠化疗诱导的免疫抑制和骨髓移植过程中体液免疫和细胞免疫反应的重建。
Stem Cells Dev. 2005 Oct;14(5):548-55. doi: 10.1089/scd.2005.14.548.
8
Stimulation of granulocytic colony formation in agar diffusion chambers implanted in cyclophosphamide pretreated mice.在植入经环磷酰胺预处理小鼠的琼脂扩散小室中刺激粒细胞集落形成。
Br J Cancer. 1975 Jul;32(1):51-9. doi: 10.1038/bjc.1975.133.
9
Growth of human hematopoietic cells in immunodeficient mice conditioned with cyclophosphamide and busulfan.经环磷酰胺和白消安预处理的免疫缺陷小鼠体内人造血细胞的生长
Stem Cells. 1997;15(4):314-23. doi: 10.1002/stem.150314.
10
A direct assay of granulocytic repopulating ability.粒细胞再增殖能力的直接测定。
Exp Hematol. 1978 Feb;6(2):135-40.

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Primitive Sca-1 Positive Bone Marrow HSC in Mouse Model of Aplastic Anemia: A Comparative Study through Flowcytometric Analysis and Scanning Electron Microscopy.流式细胞术分析和扫描电镜比较研究再生障碍性贫血小鼠模型中原始 Sca-1 阳性骨髓造血干细胞。
Stem Cells Int. 2010;2010:614395. doi: 10.4061/2010/614395. Epub 2009 Oct 28.
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The impact of redox and thiol status on the bone marrow: Pharmacological intervention strategies.氧化还原和巯基状态对骨髓的影响：药理干预策略。
Pharmacol Ther. 2011 Feb;129(2):172-84. doi: 10.1016/j.pharmthera.2010.09.008. Epub 2010 Oct 15.
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Animal models for acquired bone marrow failure syndromes.获得性骨髓衰竭综合征的动物模型。
Clin Med Res. 2005 May;3(2):102-8. doi: 10.3121/cmr.3.2.102.
4
Busulphan is active against neuroblastoma and medulloblastoma xenografts in athymic mice at clinically achievable plasma drug concentrations.白消安在无胸腺小鼠中，以临床可达到的血浆药物浓度对神经母细胞瘤和髓母细胞瘤异种移植瘤具有活性。
Br J Cancer. 1999 Feb;79(5-6):787-92. doi: 10.1038/sj.bjc.6690126.
5
The effect of treatment with high dose melphalan, cisplatin or carboplatin on levels of glutathione in plasma, erythrocytes, mononuclear cells and urine.
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Cyclophosphamide-induced lung damage in mice: protection by a small preliminary dose.环磷酰胺诱导的小鼠肺损伤：小剂量预给药的保护作用
Br J Cancer. 1980 Jun;41(6):901-7. doi: 10.1038/bjc.1980.167.
7
Cyclophosphamide and cis-dichlorodiammine platinum (11). Nonempiric scheduling to spare dose-limiting tissues in the rat.环磷酰胺和顺式二氯二氨铂（II）。大鼠中避免剂量限制组织的非经验性给药方案。
Cancer Chemother Pharmacol. 1980;4(2):103-9. doi: 10.1007/BF00254030.
8
Metabolism of high doses of cyclophosphamide.高剂量环磷酰胺的代谢
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9
[Hematopoietic stimulation for enhanced bone marrow regeneration after chemotherapy (author's transl)].化疗后促进骨髓再生的造血刺激（作者译）
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10
Priming with low doses of methyl-CCNU reduce the toxicity of high doses of methyl-CCNU and melphalan, and increase the lifespan of mice implanted with Lewis lung carcinoma.用低剂量的甲环亚硝脲进行预处理可降低高剂量甲环亚硝脲和美法仑的毒性，并延长接种Lewis肺癌的小鼠的寿命。
Br J Cancer. 1988 Mar;57(3):266-70. doi: 10.1038/bjc.1988.57.

本文引用的文献

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The effect of cyclophosphamide on hematopoietic stem cells.环磷酰胺对造血干细胞的作用。
Radiat Res. 1968 Dec;36(3):521-7.
2
Increased survival in irradiated animals treated with bacterial endotoxins.接受细菌内毒素治疗的受辐照动物存活率提高。
Am J Physiol. 1957 Oct;191(1):124-30. doi: 10.1152/ajplegacy.1957.191.1.124.
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Endotoxin protection and colony-forming units.
Radiat Res. 1967 Nov;32(3):367-82.
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Effects of bacterial endotoxin on the occurrence of spleen colonies in irradiated mice.细菌内毒素对受辐照小鼠脾集落形成的影响。
Radiat Res. 1966 Mar;27(3):369-74.
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The cloning of normal "mast" cells in tissue culture.组织培养中正常“肥大”细胞的克隆。
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6
On mouse strain differences in radiation resistance: hematopoietic death and the endogenous colony-forming unit.关于小鼠品系在辐射抗性方面的差异：造血死亡与内源性集落形成单位
Radiat Res. 1969 Sep;39(3):608-22.
7
The effect of a homologous series of dimethane-sulphonoxy-alkanes on haemopoietic colony forming units in the rat.一系列同系物二甲基磺酰氧基烷烃对大鼠造血集落形成单位的影响。
Chem Biol Interact. 1970 Dec;2(4):273-80. doi: 10.1016/0009-2797(70)90050-5.
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Granulocyte colony stimulating factor. I. Response to acute granulocytopenia.粒细胞集落刺激因子。I. 对急性粒细胞减少症的反应。
Blood. 1971 Nov;38(5):559-68.
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Effect of endotoxin on granulopoiesis and colony-stimulating factor.内毒素对粒细胞生成和集落刺激因子的影响。
N Engl J Med. 1972 Feb 3;286(5):227-32. doi: 10.1056/NEJM197202032860502.
10
Accelerated regeneration of transplanted hematopoietic stem cells in irradiated mice pretreated with cyclophosphamide.环磷酰胺预处理的受辐照小鼠体内移植造血干细胞的加速再生
Blood. 1971 Feb;37(2):196-203.

接受环磷酰胺和白消安联合剂量的小鼠致死率降低。

Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan.

作者信息

Millar J L, Hudspith B N, Blackett N M

出版信息

Br J Cancer. 1975 Aug;32(2):193-8. doi: 10.1038/bjc.1975.149.

DOI:10.1038/bjc.1975.149
PMID:764844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2024837/
Abstract

Animals treated with a sufficiently high dose of busulphan die about 14 days later from bone marrow failure. A single, appropriately timed injection of cyclophosphamide can save these mice. The nature of this protection is shown to be the cyclophosphamide induced elaboration of a humoral factor which stimulates haemopoietic recovery.

摘要

用足够高剂量白消安治疗的动物约14天后死于骨髓衰竭。单次适时注射环磷酰胺可挽救这些小鼠。这种保护的本质是环磷酰胺诱导产生一种刺激造血恢复的体液因子。