接受环磷酰胺和白消安联合剂量的小鼠致死率降低。
Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan.
作者信息
Millar J L, Hudspith B N, Blackett N M
出版信息
Br J Cancer. 1975 Aug;32(2):193-8. doi: 10.1038/bjc.1975.149.
Abstract
Animals treated with a sufficiently high dose of busulphan die about 14 days later from bone marrow failure. A single, appropriately timed injection of cyclophosphamide can save these mice. The nature of this protection is shown to be the cyclophosphamide induced elaboration of a humoral factor which stimulates haemopoietic recovery.
摘要
用足够高剂量白消安治疗的动物约14天后死于骨髓衰竭。单次适时注射环磷酰胺可挽救这些小鼠。这种保护的本质是环磷酰胺诱导产生一种刺激造血恢复的体液因子。
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本文引用的文献
1
The effect of cyclophosphamide on hematopoietic stem cells.
Radiat Res. 1968 Dec;36(3):521-7.
2
Increased survival in irradiated animals treated with bacterial endotoxins.
Am J Physiol. 1957 Oct;191(1):124-30. doi: 10.1152/ajplegacy.1957.191.1.124.
3
Endotoxin protection and colony-forming units.
Radiat Res. 1967 Nov;32(3):367-82.
4
Effects of bacterial endotoxin on the occurrence of spleen colonies in irradiated mice.
Radiat Res. 1966 Mar;27(3):369-74.
5
The cloning of normal "mast" cells in tissue culture.
J Cell Physiol. 1965 Dec;66(3):319-24. doi: 10.1002/jcp.1030660309.
6
On mouse strain differences in radiation resistance: hematopoietic death and the endogenous colony-forming unit.
Radiat Res. 1969 Sep;39(3):608-22.
7
The effect of a homologous series of dimethane-sulphonoxy-alkanes on haemopoietic colony forming units in the rat.
Chem Biol Interact. 1970 Dec;2(4):273-80. doi: 10.1016/0009-2797(70)90050-5.
8
Granulocyte colony stimulating factor. I. Response to acute granulocytopenia.
Blood. 1971 Nov;38(5):559-68.
9
Effect of endotoxin on granulopoiesis and colony-stimulating factor.
N Engl J Med. 1972 Feb 3;286(5):227-32. doi: 10.1056/NEJM197202032860502.
10
Accelerated regeneration of transplanted hematopoietic stem cells in irradiated mice pretreated with cyclophosphamide.
Blood. 1971 Feb;37(2):196-203.
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