小鼠对胎儿小肠同种异体移植的体液免疫反应。
The humoral immune response to allografts of foetal small intestine in mice.
作者信息
Elves M W, Ferguson A
出版信息
Br J Exp Pathol. 1975 Oct;56(5):454-8.
The influence of the presence of "passenger leucocytes" on the production of anti-H2 antibodies has been studied in mice receiving allografts of foetal small intestine, adult skin or intradermally injected spleen cells. It was found that the humoral immune response to foetal intestine (a tissue without passenger leucocytes) was identical temporarily to that elicited by skin allografts and these responses differed from that following injection of allogeneic spleen cells in that antibodies to solid grafts took longer to appear. The humoral immune response to small intestine grafts was not evident until several days after the onset of graft rejection as assessed morphologicallymanti H2 antibody production was not observed in thymus deprived recipients of foetal small intestine allografts or allogeneic spleen cells, and this suggests that the humoral immune response to transplantation antigens is thymus dependent.
在接受胎儿小肠、成年皮肤同种异体移植或皮内注射脾细胞的小鼠中，研究了“过客白细胞”的存在对抗H2抗体产生的影响。结果发现，对胎儿小肠（一种没有过客白细胞的组织）的体液免疫反应在短期内与皮肤同种异体移植引发的反应相同，并且这些反应与注射同种异体脾细胞后的反应不同，因为针对实体移植物的抗体出现得更慢。从形态学评估来看，对小肠移植物的体液免疫反应直到移植物排斥开始几天后才明显；在去除胸腺的胎儿小肠同种异体移植或同种异体脾细胞受体中未观察到抗H2抗体产生，这表明对移植抗原的体液免疫反应是依赖胸腺的。
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