多杀巴斯德菌毒素可诱导成纤维细胞产生白细胞介素-6，但不产生白细胞介素-1α或肿瘤坏死因子α。
Pasteurella multocida toxin induces IL-6, but not IL-1 alpha or TNF alpha in fibroblasts.
作者信息
Rosendal S, Frandsen P L, Nielsen J P, Gallily R
机构信息
Department of Veterinary Microbiology and Immunology, University of Guelph, Ontario, Canada.
出版信息
Can J Vet Res. 1995 Apr;59(2):154-6.
Abstract
Pasteurella multocida toxin (PMT) is the major virulence factor in Progressive Atrophic Rhinitis of swine. Other workers' previous findings that PMT was mitogenic for 3T3 fibroblasts, were confirmed in the present study. In addition, PMT stimulated 3T3 cells to release IL-6, but IL-1 alpha or TNF alpha were not detected in fibroblast supernatants sampled 24, 48, or 72 h after stimulation. In view of the role of IL-6 in osteoclastic bone resorption, these findings provide a new working hypothesis for investigations into the molecular pathogenesis of this important disease.
摘要
多杀性巴氏杆菌毒素（PMT）是猪进行性萎缩性鼻炎的主要毒力因子。本研究证实了其他研究人员之前的发现，即PMT对3T3成纤维细胞具有促有丝分裂作用。此外，PMT刺激3T3细胞释放白细胞介素-6（IL-6），但在刺激后24、48或72小时采集的成纤维细胞上清液中未检测到白细胞介素-1α（IL-1α）或肿瘤坏死因子-α（TNF-α）。鉴于IL-6在破骨细胞骨吸收中的作用，这些发现为研究这种重要疾病的分子发病机制提供了一个新的工作假设。
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