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In vitro activity of RP 59500 (quinupristin/dalfopristin) against antibiotic-resistant strains of Streptococcus pneumoniae and enterococci.

作者信息

Johnson C C, Slavoski L, Schwartz M, May P, Pitsakis P G, Shur A L, Levison M E

机构信息

Division of Infectious Diseases, Medical College of Pennsylvania, Philadelphia 19104, USA.

出版信息

Diagn Microbiol Infect Dis. 1995 Mar;21(3):169-73. doi: 10.1016/0732-8893(95)00068-l.

DOI:10.1016/0732-8893(95)00068-l
PMID:7648837
Abstract

The activity of RP 59500 (quinupristin/dalfopristin) was evaluated in vitro against antibiotic-resistant strains of Streptococcus pneumoniae (N = 15) and Enterococcus spp. (N = 43). By broth dilution MIC tests RP 59500 was highly active against penicillin-resistant S. pneumoniae and vancomycin-resistant Enterococcus faecium, but showed poor activity against E. faecalis. In time-kill studies the drug was rapidly bactericidal against S. pneumoniae but failed to kill most enterococci, even in the presence of gentamicin or human serum.

摘要

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