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酸性环境对幽门螺杆菌对曲古霉素及其他抗菌药物敏感性的影响。

Effect of an acidic environment on the susceptibility of Helicobacter pylori to trospectomycin and other antimicrobial agents.

作者信息

Debets-Ossenkopp Y J, Namavar F, MacLaren D M

机构信息

Department of Clinical Microbiology, Free University Hospital, Amsterdam, The Netherlands.

出版信息

Eur J Clin Microbiol Infect Dis. 1995 Apr;14(4):353-5. doi: 10.1007/BF02116532.

DOI:10.1007/BF02116532
PMID:7649202
Abstract

The susceptibility of 30 clinical isolates of Helicobacter pylori to trospectomycin, ampicillin, metronidazole, clarithromycin, azithromycin and clindamycin under varying pH conditions was evaluated. An acidic environment was shown to affect unfavourably the activity of all the antimicrobial agents tested. This pH effect was most marked for the two macrolides and for clindamycin.

摘要

评估了30株幽门螺杆菌临床分离株在不同pH条件下对曲古霉素、氨苄西林、甲硝唑、克拉霉素、阿奇霉素和克林霉素的敏感性。结果显示，酸性环境对所有测试抗菌药物的活性均有不利影响。这种pH效应在两种大环内酯类药物和克林霉素中最为明显。

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2
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