曲帕霉素（U-63366F）的抗菌活性及纸片扩散法药敏试验的初步评估
Antibacterial activity of trospectomycin (U-63366F) and initial evaluations of disk diffusion susceptibility tests.
作者信息
Barry A L, Jones R N, Thornsberry C
机构信息
Clinical Microbiology Institute, Tualatin, Oregon 97062.
出版信息
Antimicrob Agents Chemother. 1989 Apr;33(4):569-72. doi: 10.1128/AAC.33.4.569.
Abstract
The in vitro activities of trospectomycin sulfate were compared with those spectinomycin against 632 aerobic microorganisms, including 66 Neisseria gonorrhoeae isolates. Against species other than gram-negative bacilli, trospectomycin was about 4- to 16-fold more active than spectinomycin. For disk diffusion tests, a 30-micrograms disk is recommended, with tentative zone size breakpoints of less than or equal to 13 mm for resistance (MIC, greater than or equal to 64 micrograms/ml) and greater than or equal to 17 mm for susceptibility (MIC, less than or equal to 16 micrograms/ml).
摘要
将硫酸曲古抑菌素的体外活性与壮观霉素针对632种需氧微生物（包括66株淋病奈瑟菌分离株）的活性进行了比较。对于革兰氏阴性杆菌以外的菌种，曲古抑菌素的活性比壮观霉素高约4至16倍。对于纸片扩散试验，推荐使用30微克的纸片，耐药（MIC大于或等于64微克/毫升）的暂定抑菌圈大小断点为小于或等于13毫米，敏感（MIC小于或等于16微克/毫升）的暂定抑菌圈大小断点为大于或等于17毫米。
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