Schurmann A, Spencer G S, Berry C J
Ruakura Agricultural Centre, Hamilton, New Zealand.
Experientia. 1995 Aug 16;51(8):780-5. doi: 10.1007/BF01922430.
Female dwarf rats at different ages were treated with recombinant porcine GH or with a potent sheep anti-rat GH serum. Body weight and spleen weight increased with GH and decreased with anti-GH treatment (p < 0.001). Neither GH nor anti-GH treatment resulted in a change in circulating WBCs, but GH decreased, while anti-GH increased, RBC counts (p < 0.001). Similarly, GH treatment tended to decrease the ratio of CD4+:CD8+ T-cells while anti-GH increased (p < 0.05) the ratio. Anti-GH treatment also enhanced the animals' ability to produce specific IgG in response to KLH injection. These results indicate that GH may have a physiological role in suppressing humoral immune function but may enhance cell-mediated immunity.
用重组猪生长激素或高效羊抗大鼠生长激素血清对不同年龄的雌性侏儒大鼠进行处理。生长激素处理使体重和脾脏重量增加，而抗生长激素处理则使其降低（p < 0.001）。生长激素和抗生长激素处理均未导致循环白细胞数量发生变化，但生长激素使红细胞计数降低，而抗生长激素使其升高（p < 0.001）。同样，生长激素处理倾向于降低CD4⁺:CD8⁺ T细胞比例，而抗生长激素处理则使其升高（p < 0.05）。抗生长激素处理还增强了动物对钥孔戚血蓝蛋白注射产生特异性IgG的能力。这些结果表明，生长激素可能在抑制体液免疫功能方面具有生理作用，但可能增强细胞介导的免疫。
