Brown G C
Department of Biochemistry, University of Cambridge, UK.
FEBS Lett. 1995 Aug 7;369(2-3):136-9. doi: 10.1016/0014-5793(95)00763-y.
Nitric oxide (NO) reversibly inhibits mitochondrial respiration by competing with oxygen at cytochrome oxidase. Concentrations of NO measured in a range of biological systems are similar to those shown to inhibit cytochrome oxidase and mitochondrial respiration. Inhibition of NO synthesis results in a stimulation of respiration in a number of systems. It is proposed that NO exerts some of its main physiological and pathological effects on cell functions by inhibiting cytochrome oxidase. Further NO may be a physiological regulator of the affinity of mitochondrial respiration for oxygen, enabling mitochondria to act as sensors of oxygen over the physiological range.
一氧化氮（NO）通过在细胞色素氧化酶处与氧竞争，可逆地抑制线粒体呼吸。在一系列生物系统中测得的NO浓度与那些已显示能抑制细胞色素氧化酶和线粒体呼吸的浓度相似。在许多系统中，抑制NO合成会导致呼吸增强。有人提出，NO通过抑制细胞色素氧化酶对细胞功能发挥其一些主要的生理和病理作用。此外，NO可能是线粒体呼吸对氧亲和力的一种生理调节因子，使线粒体能够在生理范围内充当氧传感器。
