与血吸虫病相关且由人乳头瘤病毒引起的子宫颈癌。
Carcinoma of the uterine cervix associated with schistosomiasis and induced by human papillomaviruses.
作者信息
Moubayed P, Ziehe A, Peters J, Mwakyoma H, Schmidt D
机构信息
Institute of Pathology, Medical University of Lübeck, Germany.
出版信息
Int J Gynaecol Obstet. 1995 May;49(2):175-9. doi: 10.1016/0020-7292(95)02332-7.
OBJECTIVES
To determine the presence of human papillomaviruses (HPVs) in cervical cancer among patients in Tanzania and to ascertain their prevalence in cases associated with schistosomiasis.
METHODS
In situ hybridization was applied to 31 carcinomas of the uterine cervix including 10 in which schistosomiasis co-occurred. Twenty-six cases in this series also exhibited koilocytic dysplasia.
RESULTS
Twenty-six out of 31 cases revealed a specific hybridization for HPVs with varying density and distribution. A slightly higher labeling of HPV-16 than -18 was demonstrated. All schistosomiasis-associated cancers encoded the papillomaviruses. The 31 patients were predominantly young adults, a fact that reflects sexual activity at a very young age in the ethnic communities of Africa.
CONCLUSION
These findings shed new light on the presumed etiologic implication of schistosomiasis in the genesis of cervical cancer. In the absence of HPV, schistosomiasis is not the oncogenic causative agent for carcinoma of the uterine cervix.
目的
确定坦桑尼亚患者宫颈癌中人类乳头瘤病毒（HPV）的存在情况，并确定其在与血吸虫病相关病例中的患病率。
方法
对31例子宫颈癌进行原位杂交，其中10例同时存在血吸虫病。该系列中的26例还表现出挖空细胞发育异常。
结果
31例中有26例显示HPV的特异性杂交，其密度和分布各不相同。HPV-16的标记略高于HPV-18。所有与血吸虫病相关的癌症都编码乳头瘤病毒。这31名患者主要是年轻人，这一事实反映了非洲种族社区中非常年轻的性行为。
结论
这些发现为血吸虫病在宫颈癌发生中假定的病因学意义提供了新的线索。在没有HPV的情况下，血吸虫病不是子宫颈癌的致癌病原体。
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