Goldwater P N
Microbiology and Infectious Disease Service, Women's and Children's Hospital, North Adelaide, Australia.
J Clin Microbiol. 1995 Jun;33(6):1628-31. doi: 10.1128/jcm.33.6.1628-1631.1995.
An immunoglobulin M (IgM) capture enzyme immunoassay was used to detect major overlapping outbreaks of disease in South Australia caused by coxsackieviruses B5 (CBV-5) and B6 (CBV-6). CBV-5-specific IgM was detected in patients presenting in spring 1992 with acute febrile illnesses, rash, severe acute respiratory disease, meningitis, myocarditis and/or pericarditis, while tests for other viruses were negative. CBV-5 was isolated from an early case. In December 1992 it was noted that CBV-6 had replaced CBV-5 as the major cause of disease. The CBV-6 epidemic continued until April 1993. Serum samples from 495 patients (276 inpatients) were submitted for testing. CBV-6 infection was associated with lower respiratory tract infection and persistent cough. This study demonstrated success of the IgM enzyme immunoassay and the need for diagnostic virology laboratories to look for CBV-6 infection in addition to the other five CBVs.
采用免疫球蛋白M（IgM）捕获酶免疫测定法检测南澳大利亚由柯萨奇病毒B5（CBV-5）和B6（CBV-6）引起的主要重叠疾病暴发。在1992年春季出现急性发热性疾病、皮疹、严重急性呼吸道疾病、脑膜炎、心肌炎和/或心包炎的患者中检测到CBV-5特异性IgM，而其他病毒检测均为阴性。从早期病例中分离出CBV-5。1992年12月，注意到CBV-6已取代CBV-5成为主要致病原因。CBV-6疫情持续到1993年4月。提交了495例患者（276例住院患者）的血清样本进行检测。CBV-6感染与下呼吸道感染和持续性咳嗽有关。本研究证明了IgM酶免疫测定法的成功，以及诊断病毒学实验室除检测其他五种柯萨奇病毒B型外还需查找CBV-6感染的必要性。
