Bentolila S, Radenne S, Horellou M H, Conard J, Samama M M
Service d'Hématologie Biologique, Hôtel-Dieu, Paris.
J Mal Vasc. 1995;20(2):95-101.
Among iatrogenic complications of oral anticoagulation, hemorrhagic complications are the most frequent and potentially lethal. The major hemorrhagic risk is the intensity of anticoagulation. A decrease of this risk is obtained with tapering of INR. Age, sex, anticoagulant therapy, and other personal risk factors as duration of anticoagulation, are factors not admitted by all the authors. Our experience at Hôtel-Dieu University Hospital and the literature data provide evidence that patient follow-up in a specialized center should decrease the incidence of hemorrhagic complications.
在口服抗凝治疗的医源性并发症中,出血性并发症最为常见且可能致命。主要的出血风险在于抗凝强度。通过逐渐降低国际标准化比值(INR)可降低此风险。年龄、性别、抗凝治疗以及其他个人风险因素(如抗凝持续时间),并非所有作者都认可这些因素。我们在迪厄医院大学附属医院的经验以及文献数据表明,在专业中心对患者进行随访应可降低出血性并发症的发生率。