In vitro susceptibility to itraconazole and fluconazole of switch phenotypes of Candida albicans serotypes A and B, isolated from immunocompromised hosts.

Data from 78 oropharyngeal samples obtained from severely immunocompromised individuals, have shown that the B serotype and the stipple phenotype of Candida albicans isolates have significantly higher minimum inhibitory concentration values towards itraconazole and fluconazole, as compared with the corresponding serotype A phenotype (P < 0.05). The epidemiological significance of the phenotype-dependent drug susceptibility patterns is discussed.