从感染人类免疫缺陷病毒的患者中分离出的口咽白色念珠菌菌株中的唑类耐药性。
Azole resistance in oropharyngeal Candida albicans strains isolated from patients infected with human immunodeficiency virus.
作者信息
He X, Tiballi R N, Zarins L T, Bradley S F, Sangeorzan J A, Kauffman C A
机构信息
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor.
出版信息
Antimicrob Agents Chemother. 1994 Oct;38(10):2495-7. doi: 10.1128/AAC.38.10.2495.
Abstract
For 212 oropharyngeal isolates of Candida albicans, the fluconazole MICs for 50 and 90% of strains tested were 0.5 and 16 micrograms/ml, respectively, and those of itraconazole were 0.05 and 0.2 micrograms/ml, respectively. Of 16 isolates for which fluconazole MICs were > 64 micrograms/ml, itraconazole MICs for 14 were < or = 0.8 micrograms/ml and for 2 were > 6.4 micrograms/ml. Most fluconazole-resistant strains remained susceptible to itraconazole; whether itraconazole will prove effective for refractory thrush remains to be shown.
摘要
对于212株白色念珠菌口咽分离株，测试的50%和90%菌株的氟康唑最低抑菌浓度（MIC）分别为0.5微克/毫升和16微克/毫升，伊曲康唑的MIC分别为0.05微克/毫升和0.2微克/毫升。在氟康唑MIC>64微克/毫升的16株分离株中，14株的伊曲康唑MIC≤0.8微克/毫升，2株的伊曲康唑MIC>6.4微克/毫升。大多数耐氟康唑菌株对伊曲康唑仍敏感；伊曲康唑对难治性鹅口疮是否有效仍有待证实。
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