Roser W, Hagberg G, Mader I, Brunnschweiler H, Radue E W, Seelig J, Kappos L
MR Center and Biocenter, University Hospital, University of Basel, Switzerland.
Magn Reson Med. 1995 Jun;33(6):811-7. doi: 10.1002/mrm.1910330611.
Localized short echo time (TE = 20 ms), stimulated echo acquisition mode, and double spin echo (TE = 135 ms) proton spectroscopy were performed in clearly defined, acute Gadolinium (Gd)-enhancing multiple sclerosis (MS) plaques of 22 patients with clinically definite MS. The resonances of N-acetylated metabolites (NA), creatine/phosphocreatine (Cr), choline-containing compounds (Cho), glycine/myo-inositol (Ino), and lactate were evaluated. The ratios of NA/Cr and NA/Cho were significantly decreased, Cho/Cr increased, and Ino/Cr remained unchanged. No marker peaks or elevated lactate levels were found. The measured metabolic changes were practically independent of the relative plaque size within the volume of interest (8 ml). Thus, the spectral changes measured with 1H MRS in acute Gd-enhancing MS plaques originate not only from the lesion as depicted by MRI, but also from the surrounding normal-appearing white matter.
对22例临床确诊为多发性硬化症（MS）患者明确的急性钆（Gd）强化多发性硬化斑块进行局部短回波时间（TE = 20毫秒）、受激回波采集模式和双自旋回波（TE = 135毫秒）质子波谱分析。评估了N - 乙酰化代谢物（NA）、肌酸/磷酸肌酸（Cr）、含胆碱化合物（Cho）、甘氨酸/肌醇（Ino）和乳酸的共振情况。NA/Cr和NA/Cho比值显著降低，Cho/Cr升高，Ino/Cr保持不变。未发现标记峰或乳酸水平升高。所测得的代谢变化实际上与感兴趣体积（8毫升）内相对斑块大小无关。因此，用1H MRS在急性Gd强化MS斑块中测得的波谱变化不仅源于MRI所显示的病变，还源于周围外观正常的白质。
