Van Hecke P, Marchal G, Johannik K, Demaerel P, Wilms G, Carton H, Baert A L
Department of Radiology, University Hospitals K. U. Leuven, Belgium.
Magn Reson Med. 1991 Mar;18(1):199-206. doi: 10.1002/mrm.1910180120.
Localized proton spectroscopy of the brain was performed on MS patients (n = 18) and the results are compared with those of a control group (n = 17). The experiments were performed in a 1.5-T Siemens Magnetom using the stimulated echo method and selective water suppression. Acquisition parameters were TR/TE/TM = 3000/270/30 ms, NA = 256, and Acq = 13 min. Localized volumes ranged from 8 to about 80 cc. The patients (ages 25 to 66) were at various stages of the disease. Three of the eighteen patients did not show any plaques on the MR images. VOIs were chosen to contain as much plaque volume as possible in the cerebrum white matter. In the controls and in the patients with no plaques, the VOI were localized in similar white matter regions. All spectra were characterized by the presence of Cho (3.2 ppm), PCr + Cr (3.0 ppm), and NAA (2.0 ppm). The ratios NAA/Cho and NAA/(PCr + Cr) were calculated for both the MS and the control group. The results for the three MS patients with no detectable plaques did not differ significantly from the results of the control group. The former group is, however, too limited to draw any conclusion for the moment. For the MRI positive patients, the following values were found (means +/- 1 SD); NAA/Cho = 1.98 +/- 0.33 and NAA/(PCr + Cr) = 2.16 +/- 0.14. In the normals, these values were NAA/Cho = 2.54 +/- 0.39 and NAA/(PCr + Cr) = 2.76 +/- 0.25. The results quoted are TR and TE dependent.(ABSTRACT TRUNCATED AT 250 WORDS)
对18例多发性硬化症（MS）患者进行了脑部局部质子光谱分析，并将结果与17例对照组患者的结果进行了比较。实验在1.5T西门子Magnetom上使用受激回波方法和选择性水抑制进行。采集参数为TR/TE/TM = 3000/270/30毫秒，NA = 256，采集时间为13分钟。局部体积范围为8至约80立方厘米。患者年龄在25至66岁之间，处于疾病的不同阶段。18例患者中有3例在磁共振图像上未显示任何斑块。感兴趣区（VOI）的选择是为了在大脑白质中包含尽可能多的斑块体积。在对照组和无斑块的患者中，VOI位于相似的白质区域。所有光谱均以存在胆碱（Cho，3.2 ppm）、磷酸肌酸+肌酸（PCr + Cr，3.0 ppm）和N-乙酰天门冬氨酸（NAA，2.0 ppm）为特征。计算了MS组和对照组的NAA/Cho和NAA/(PCr + Cr)比值。3例未检测到斑块的MS患者的结果与对照组的结果无显著差异。然而，前一组样本量太小，目前无法得出任何结论。对于MRI呈阳性的患者，得到以下值（平均值±1标准差）；NAA/Cho = 1.98 ± 0.33，NAA/(PCr + Cr) = 2.16 ± 0.14。在正常组中，这些值为NAA/Cho = 2.54 ± 0.39，NAA/(PCr + Cr) = 2.76 ± 0.25。所引用的结果取决于TR和TE。（摘要截断于250字）
