一种果蝇CREB/CREM同源物编码多种异构体，包括一种环磷酸腺苷依赖性蛋白激酶反应性转录激活剂和拮抗剂。
A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist.
作者信息
Yin J C, Wallach J S, Wilder E L, Klingensmith J, Dang D, Perrimon N, Zhou H, Tully T, Quinn W G
机构信息
Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge 02139, USA.
出版信息
Mol Cell Biol. 1995 Sep;15(9):5123-30. doi: 10.1128/MCB.15.9.5123.
Abstract
We have characterized a Drosophila gene that is a highly conserved homolog of the mammalian cyclic AMP (cAMP)-responsive transcription factors CREB and CREM. Uniquely among Drosophila genes characterized to date, it codes for a cAMP-responsive transcriptional activator. An alternatively spliced product of the same gene is a specific antagonist of cAMP-inducible transcription. Analysis of the splicing pattern of the gene suggests that the gene may be the predecessor of the mammalian CREB and CREM genes.
摘要
我们已经鉴定出一个果蝇基因，它是哺乳动物环磷酸腺苷（cAMP）反应性转录因子CREB和CREM的高度保守同源物。在迄今为止已鉴定的果蝇基因中，它独特地编码一种cAMP反应性转录激活因子。同一基因的一个选择性剪接产物是cAMP诱导转录的特异性拮抗剂。对该基因剪接模式的分析表明，该基因可能是哺乳动物CREB和CREM基因的前身。
相似文献
1
A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist.一种果蝇CREB/CREM同源物编码多种异构体，包括一种环磷酸腺苷依赖性蛋白激酶反应性转录激活剂和拮抗剂。
Mol Cell Biol. 1995 Sep;15(9):5123-30. doi: 10.1128/MCB.15.9.5123.
2
Human endometrial stromal cells express novel isoforms of the transcriptional modulator CREM and up-regulate ICER in the course of decidualization.人子宫内膜基质细胞在蜕膜化过程中表达转录调节因子CREM的新型异构体并上调ICER。
Mol Endocrinol. 1997 Jan;11(1):97-113. doi: 10.1210/mend.11.1.9875.
3
An isoform of transcription factor CREM expressed during spermatogenesis lacks the phosphorylation domain and represses cAMP-induced transcription.在精子发生过程中表达的转录因子CREM的一种异构体缺乏磷酸化结构域，并抑制cAMP诱导的转录。
Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12423-7. doi: 10.1073/pnas.91.26.12423.
4
The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis.参与精子发生的CREB/CREM转录因子家族不断扩大。
Mol Cell Endocrinol. 2002 Feb 22;187(1-2):115-24. doi: 10.1016/s0303-7207(01)00696-7.
5
Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript.人类CREM基因：进化保守性、染色体定位及转录本的可诱导性。
Cell Growth Differ. 1993 Nov;4(11):931-7.
6
Transcriptional response to cAMP in brain: specific distribution and induction of CREM antagonists.大脑中对环磷酸腺苷（cAMP）的转录反应：CREM拮抗剂的特异性分布与诱导
Neuron. 1993 Apr;10(4):655-65. doi: 10.1016/0896-6273(93)90167-p.
7
Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family.环磷酸腺苷反应元件结合蛋白家族成员对类固醇生成及类固醇生成急性调节蛋白的调控
Mol Endocrinol. 2002 Jan;16(1):184-99. doi: 10.1210/mend.16.1.0759.
8
Two evolutionarily conserved repression domains in the Drosophila Kruppel protein differ in activator specificity.果蝇克虏伯蛋白中两个进化上保守的抑制结构域在激活剂特异性上存在差异。
Mol Cell Biol. 1997 Aug;17(8):4820-9. doi: 10.1128/MCB.17.8.4820.
9
Mechanisms of activation by CREB and CREM: phosphorylation, CBP, and a novel coactivator, ACT.CREB和CREM的激活机制：磷酸化、CBP以及一种新型共激活因子ACT。
Cold Spring Harb Symp Quant Biol. 1998;63:631-42. doi: 10.1101/sqb.1998.63.631.
10
Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors.转录因子CREB中依赖蛋白激酶A的激活剂揭示了CREM阻遏物的新作用。
Nature. 1993 Aug 26;364(6440):821-4. doi: 10.1038/364821a0.
引用本文的文献
1
Multi-faceted regulation of CREB family transcription factors.CREB家族转录因子的多方面调控
Front Mol Neurosci. 2024 Aug 6;17:1408949. doi: 10.3389/fnmol.2024.1408949. eCollection 2024.
2
Memory phase-specific genes in the Mushroom Bodies identified using CrebB-target DamID.使用 CrebB 靶标 DamID 鉴定蘑菇体中的记忆相特异性基因。
PLoS Genet. 2023 Jun 12;19(6):e1010802. doi: 10.1371/journal.pgen.1010802. eCollection 2023 Jun.
3
M1BP is an essential transcriptional activator of oxidative metabolism during Drosophila development.M1BP 是果蝇发育过程中氧化代谢所必需的转录激活因子。
Nat Commun. 2023 Jun 2;14(1):3187. doi: 10.1038/s41467-023-38986-5.
4
CREBB repression of protein synthesis in mushroom body gates long-term memory formation in .CREBB 对蘑菇体中蛋白质合成的抑制作用控制着长期记忆的形成。
Proc Natl Acad Sci U S A. 2022 Dec 13;119(50):e2211308119. doi: 10.1073/pnas.2211308119. Epub 2022 Dec 5.
5
CREBA and CREBB in two identified neurons gate long-term memory formation in .CREBA 和 CREBB 在两种确定的神经元中控制着长期记忆的形成。
Proc Natl Acad Sci U S A. 2021 Sep 14;118(37). doi: 10.1073/pnas.2100624118.
6
Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium.致病 Tau 导致核钙的毒性耗竭。
Cell Rep. 2020 Jul 14;32(2):107900. doi: 10.1016/j.celrep.2020.107900.
7
Cellular and circuit mechanisms of olfactory associative learning in .嗅觉联想学习的细胞和回路机制。
J Neurogenet. 2020 Mar;34(1):36-46. doi: 10.1080/01677063.2020.1715971. Epub 2020 Feb 11.
8
Recurrent Circuitry Sustains Drosophila Courtship Drive While Priming Itself for Satiety.反复的回路维持果蝇求爱驱动，同时为饱食做准备。
Curr Biol. 2019 Oct 7;29(19):3216-3228.e9. doi: 10.1016/j.cub.2019.08.015. Epub 2019 Aug 29.
9
Drosophila CrebB is a Substrate of the Nonsense-Mediated mRNA Decay Pathway that Sustains Circadian Behaviors.果蝇 CrebB 是无意义介导的 mRNA 降解途径的底物，该途径维持昼夜节律行为。
Mol Cells. 2019 Apr 30;42(4):301-312. doi: 10.14348/molcells.2019.2451.
10
How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory.记忆如何能持续数天、数年甚至一生？维持突触增强和记忆的提出机制。
Learn Mem. 2019 Apr 16;26(5):133-150. doi: 10.1101/lm.049395.119. Print 2019 May.
本文引用的文献
1
The functional versatility of CREM is determined by its modular structure.CREM的功能多样性由其模块化结构决定。
EMBO J. 1993 Mar;12(3):1179-91. doi: 10.1002/j.1460-2075.1993.tb05759.x.
2
Phosphorylated CREB binds specifically to the nuclear protein CBP.磷酸化的环磷腺苷反应元件结合蛋白（CREB）特异性地与核蛋白CBP结合。
Nature. 1993 Oct 28;365(6449):855-9. doi: 10.1038/365855a0.
3
Isolation of Drosophila CREB-B: a novel CRE-binding protein.
DNA Cell Biol. 1993 Sep;12(7):589-95. doi: 10.1089/dna.1993.12.589.
4
Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal gland.肾上腺素能信号指导松果体中转录抑制因子CREM的节律性表达。
Nature. 1993 Sep 23;365(6444):314-20. doi: 10.1038/365314a0.
5
Genetic investigation of cAMP-dependent protein kinase function in Drosophila development.果蝇发育过程中cAMP依赖性蛋白激酶功能的遗传学研究。
Genes Dev. 1993 Jul;7(7A):1229-43. doi: 10.1101/gad.7.7a.1229.
6
Hormonal control of gene expression: multiplicity and versatility of cyclic adenosine 3',5'-monophosphate-responsive nuclear regulators.基因表达的激素调控：3',5'-环磷酸腺苷应答性核调节因子的多样性与多功能性
Mol Endocrinol. 1993 Feb;7(2):145-53. doi: 10.1210/mend.7.2.8385737.
7
Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation.激活转录因子-1可介导钙离子和环磷酸腺苷诱导的转录激活。
J Biol Chem. 1993 Mar 25;268(9):6714-20.
8
Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A.通过环磷酸腺苷反应元件结合蛋白（CREB）实现的激素刺激与转录的偶联受蛋白激酶A进入细胞核的速率限制。
Mol Cell Biol. 1993 Aug;13(8):4852-9. doi: 10.1128/mcb.13.8.4852-4859.1993.
9
Drosophila hedgehog acts as a morphogen in cellular patterning.果蝇的刺猬蛋白在细胞模式形成中作为一种形态发生素发挥作用。
Cell. 1994 Feb 11;76(3):449-60. doi: 10.1016/0092-8674(94)90110-4.
10
Zotero 插件