Pearce R K, Hawkes C H, Daniel S E
UK Parkinson's Disease Society Brain Bank, Institute of Neurology, London, England.
Mov Disord. 1995 May;10(3):283-7. doi: 10.1002/mds.870100309.
Impaired olfaction occurs in patients with idiopathic Parkinson's disease (PD), and Lewy bodies have been found in the olfactory bulb and tract. We now confirm the latter finding and show that this presence of Lewy bodies is associated with significant neuronal loss. A quantitative study of the anterior olfactory nucleus (AON) was performed in tissue obtained postmortem from seven patients with PD and seven age-matched controls. Neuronal loss was seen in the PD bulb and tracts (p < 0.01), and a strong correlation of neuronal loss with disease duration was detected (R = -0.87). The presence of Lewy bodies was confirmed with immunocytochemical staining for ubiquitin in all the PD cases.
特发性帕金森病（PD）患者存在嗅觉减退，且在嗅球和嗅束中发现了路易小体。我们现在证实了后者的发现，并表明路易小体的存在与显著的神经元丢失有关。对7例PD患者和7例年龄匹配的对照者死后获得的组织进行了前嗅核（AON）的定量研究。在PD患者的嗅球和嗅束中观察到神经元丢失（p < 0.01），并且检测到神经元丢失与疾病持续时间之间存在强相关性（R = -0.87）。通过对所有PD病例进行泛素免疫细胞化学染色证实了路易小体的存在。
