Suchowersky O, Furtado S, Rohs G
Movement Disorders Clinic, University of Calgary, Alberta, Canada.
Mov Disord. 1995 May;10(3):337-40. doi: 10.1002/mds.870100318.
Patients with Parkinson's disease (PD) are known to experience autonomic nervous system dysfunction: this disruptive symptomatology includes urinary urgency, frequency, and nocturnal polyuria. Anticholinergic and tricyclic medications can be beneficial in controlling these urinary symptoms, but have unpleasant side effects in some patients. Desmopressin has been used to treat nocturnal polyuria successfully in a number of conditions, such as central diabetes insipidus, enuresis, and autonomic failure. The purpose of the present study was to assess the efficacy of desmopressin in patients with PD with significant nocturia. Eight patients were recruited into the study. They were first asked to establish a baseline of number of nocturnal voids; the patients were then prescribed the intranasal form of desmopressin and asked to continue to record the number of nocturnal voids. The five patients who completed the trial demonstrated clinically and statistically significant reductions in the frequency of nocturnal voids. One patient became hyponatremic and confused during desmopressin administration; his symptoms resolved soon after the desmopressin was discontinued. Two patients failed to complete the trial due to compliance problems. Thus, desmopressin appears to be a safe and effective medication for nocturnal polyuria in PD.
已知帕金森病（PD）患者会出现自主神经系统功能障碍：这种破坏性症状包括尿急、尿频和夜尿症。抗胆碱能药物和三环类药物在控制这些泌尿系统症状方面可能有益，但在一些患者中会有令人不适的副作用。去氨加压素已成功用于治疗多种病症中的夜尿症，如中枢性尿崩症、遗尿症和自主神经功能衰竭。本研究的目的是评估去氨加压素对有明显夜尿症的PD患者的疗效。八名患者被纳入该研究。他们首先被要求确定夜尿次数的基线；然后给患者开了鼻内用去氨加压素，并要求他们继续记录夜尿次数。完成试验的五名患者在夜间排尿频率上显示出临床和统计学上的显著降低。一名患者在使用去氨加压素期间出现低钠血症和意识模糊；停用去氨加压素后不久，他的症状就消失了。两名患者因依从性问题未能完成试验。因此，去氨加压素似乎是治疗PD患者夜尿症的一种安全有效的药物。
