Chatani M, Matayoshi Y, Masaki N, Inoue T
Department of Radiation Therapy, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka University Medical School, Japan.
Strahlenther Onkol. 1997 Jul;173(7):379-84. doi: 10.1007/BF03038241.
To investigate the adverse effect of treatment prolongation on the local control and survival of the cervical carcinoma of the uterus.
Two hundred and sixteen patients with stage IIB and III cervical carcinoma treated with a combination of external radiation and high-dose rate (HDR) intracavitary irradiation between 1978 and 1989 were retrospectively studied. A multivariate analysis was used to determine the effect of treatment time on local control and survival.
Overall treatment time was the most highly significant factors for local control in the multivariate analysis (p = 0.0005). The 5-year cumulative relapse rates were significantly different with the treatment times 35 to 42 days: 9% versus 43 to 49 days: 19% versus 50 to 62 days: 42% (p = 0.001). The second most significant parameter was stage classification (p = 0.02). Concerning relapse-free survival, stage classification (p = 0.0001), overall treatment time (p = 0.0035) and hemoglobin level (p = 0.0174) were the 3 most important prognostic factors, although there was no relationship between treatment time and late complications.
These results suggest that prolongation of treatment time is associated with decreased local control and survival in patients treated with external radiation and HDR intracavitary irradiation.
探讨延长治疗时间对子宫颈癌局部控制和生存的不良影响。
回顾性研究了1978年至1989年间接受外照射和高剂量率（HDR）腔内照射联合治疗的216例IIB期和III期子宫颈癌患者。采用多因素分析确定治疗时间对局部控制和生存的影响。
在多因素分析中，总治疗时间是局部控制的最显著因素（p = 0.0005）。治疗时间为35至42天、43至49天、50至62天时，5年累积复发率有显著差异：分别为9%、19%、42%（p = 0.001）。第二显著的参数是分期（p = 0.02）。关于无复发生存，分期（p = 0.0001）、总治疗时间（p = 0.0035）和血红蛋白水平（p = 0.0174）是3个最重要的预后因素，尽管治疗时间与晚期并发症之间没有关系。
这些结果表明，延长治疗时间与接受外照射和HDR腔内照射治疗的患者局部控制和生存率降低有关。
