Tannock G W, Savage D C
Infect Immun. 1976 Jan;13(1):172-9. doi: 10.1128/iai.13.1.172-179.1976.
Germfree CD-1 mice challenged by the oral route with Salmonella typhimurium had ceca that were abnormal in appearance and reduced in size compared to those of germfree controls. Similarly, germfree mice injected with heat-killed S. typhimurium or gnotobiotes associated with three indigenous microbes (Lactobacillus, Bacteroides, Clostridium), and subsequently challenged with S. typhimurium also had small ceca. By contrast, gnotobiotic mice that had been both injected with the heat-killed S. typhimurium and associated with the three indigenous microbes before challenge with S. typhimurium had ceca similar in size and appearance to germfree mice. Thus, indigenous microorganisms could interfere with the mechanism by which the pathogen induced the decrease in cecal size, but could do so only in mice injected with heat-killed bacteria. This phenomenon suggests synergism between the interference effected by the indigenous bacteria and the resistance mechanisms of the animal.
经口用鼠伤寒沙门氏菌攻击的无菌CD-1小鼠，其盲肠外观异常，与无菌对照小鼠相比，大小减小。同样，注射热灭活鼠伤寒沙门氏菌或与三种本土微生物（乳酸杆菌、拟杆菌、梭菌）相关的悉生动物小鼠，随后用鼠伤寒沙门氏菌攻击，其盲肠也较小。相比之下，在受到鼠伤寒沙门氏菌攻击之前，既注射了热灭活鼠伤寒沙门氏菌又与三种本土微生物相关联的悉生动物小鼠，其盲肠在大小和外观上与无菌小鼠相似。因此，本土微生物可干扰病原体诱导盲肠大小减小的机制，但仅在注射热灭活细菌的小鼠中才会如此。这种现象表明本土细菌产生的干扰与动物的抵抗机制之间存在协同作用。
