[从用于培养百日咳博德特氏菌的合成和半合成培养基中分离出的抗原复合物的比较分析]

[A comparative analysis of the antigenic complexes isolated from synthetic and semisynthetic media for the cultivation of Bordetella pertussis].

作者信息

Semina I E, Bazhanova I G, Melikhov V I, Chechot V A, Mileĭkovskaia M M, Mertsalova N U, Shmeleva E I, Remova T N, Sukhinova E E, Ozeretskovskaia M N

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1995 Mar-Apr(2):87-92.

Abstract

Some physicochemical properties of B.pertussis antigenic complexes isolated from synthetic and semisynthetic culture media have been studied. The chemical composition of these complexes has been determined. Proteins, polypeptide subunits and lipopolysaccharide forming these complexes have been characterized. The presence of two main protective substances of B.pertussis has been revealed: fimbrial hemagglutinin and B.pertussis toxin. The influence of culture medium on the level of the synthesis of B.pertussis adenylate cyclase has been studied.

摘要

对从合成和半合成培养基中分离出的百日咳博德特氏菌抗原复合物的一些物理化学性质进行了研究。已确定这些复合物的化学组成。对构成这些复合物的蛋白质、多肽亚基和脂多糖进行了表征。已揭示出百日咳博德特氏菌的两种主要保护性物质的存在：菌毛血凝素和百日咳博德特氏菌毒素。研究了培养基对百日咳博德特氏菌腺苷酸环化酶合成水平的影响。

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