Brown C M, Rees W D
Department of Medicine, Gloucestershire Royal Hospital, Gloucester, UK.
Aliment Pharmacol Ther. 1995 Jun;9(3):251-62. doi: 10.1111/j.1365-2036.1995.tb00379.x.
Reflux of gastric acid and pepsins into the lower oesophagus causes symptoms such as heartburn and nausea, and tissue injury leading to erosive oesophagitis and stricture formation. This article reviews the mechanisms involved in protecting the oesophagus against acid-mediated injury, including the role of the lower oesophageal sphincter, secondary oesophageal peristalsis and swallowed saliva. The oesophageal mucosa has inherent abilities to resist acid damage, and recent data from three laboratories suggest a secretory function with local production of bicarbonate and mucus responsive to local acidification. The evidence for these putative oesophageal defence mechanisms is discussed.
胃酸和胃蛋白酶反流至食管下段会引发烧心、恶心等症状，以及导致糜烂性食管炎和狭窄形成的组织损伤。本文综述了食管抵御酸介导损伤的相关机制，包括食管下括约肌、食管继发性蠕动及吞咽唾液的作用。食管黏膜具有抵抗酸损伤的内在能力，最近来自三个实验室的数据表明其具有一种分泌功能，可对局部酸化作出反应，局部产生碳酸氢盐和黏液。文中讨论了这些假定的食管防御机制的证据。
