Sanford E J, Drago J R, Rohner T J, Santen R, Lipton A
J Urol. 1976 Feb;115(2):170-4. doi: 10.1016/s0022-5347(17)59121-1.
Complete adrenal suppression with aminoglutethimide has been accomplished in 7 patients with progressive stage D carcinoma of the prostate who had become refractory to orchiectomy and the administration of exogenous estrogens. A favorable response was noted in 3 patients. These preliminary results indicate that this agent may be as useful as surgical adrenalectomy in the treatment of progressive prostatic carcinoma. A brief discussion of the pharmacology of this agent, its mode of administration and the side effects are presented.
氨鲁米特已使7例前列腺D期进展性癌患者实现了完全肾上腺抑制，这些患者对睾丸切除术和外源性雌激素治疗已产生耐药。3例患者出现了良好反应。这些初步结果表明，该药物在治疗进展性前列腺癌方面可能与手术去肾上腺同样有效。本文简要讨论了该药物的药理学、给药方式及副作用。
