Goodin D S, Squires K C, Henderson B H, Starr A
Electroencephalogr Clin Neurophysiol. 1978 Apr;44(4):447-58. doi: 10.1016/0013-4694(78)90029-9.
Auditory evoked potentials were recorded from 47 subjects ranging in age from 6 to 76 years in order to assess the effects of maturation and aging on the evoked (N1 and P2) and event-related (N2 and P3) components. Because of clear differences in the effects of age on the event-related components between children (less than 15 years of age) and adults the subjects were divided into two populations for analysis. For adults there was a systematic increase in the latency and decrease in amplitude of each component with age. Also the rate of the age-related increase in latency was proportional to the latency of the component. The scalp distributions of both the stimulus-evoked and event-related components were found to vary with age yielding a more nearly equipotential distribution for older subjects. For children the latencies of the event-related components decreased with age. The stimulus-evoked components had latencies which were not significantly different from those predicted from the adult data. In contrast to the adult data, age affected the scalp distributions of the stimulus-evoked components differently than the event-related components. These results suggest an aging process is relfected in the auditory evoked potential which is not the simple inverse of maturational processes.
为了评估成熟和衰老对诱发电位（N1和P2）以及事件相关电位（N2和P3）成分的影响，对47名年龄在6岁至76岁之间的受试者进行了听觉诱发电位记录。由于儿童（小于15岁）和成年人在年龄对事件相关电位成分的影响上存在明显差异，因此将受试者分为两组进行分析。对于成年人，随着年龄增长，每个成分的潜伏期有系统性增加，波幅减小。此外，与年龄相关的潜伏期增加速率与该成分的潜伏期成正比。发现刺激诱发电位成分和事件相关电位成分的头皮分布均随年龄变化，老年受试者的分布更接近等电位分布。对于儿童，事件相关电位成分的潜伏期随年龄减小。刺激诱发电位成分的潜伏期与根据成人数据预测的潜伏期无显著差异。与成人数据相反，年龄对刺激诱发电位成分头皮分布的影响与对事件相关电位成分的影响不同。这些结果表明，听觉诱发电位反映了一个衰老过程，而这并非成熟过程的简单逆过程。
