Hong J J, Elmore J F, Drachenberg C I, Jacobs M C, Salazar O M
Department of Radiation Oncology, University of Maryland Hospital, Baltimore, USA.
Dermatol Surg. 1995 Sep;21(9):781-5. doi: 10.1111/j.1524-4725.1995.tb00296.x.
Malignant sweat gland neoplasms are exceedingly rare tumors. Malignant chondroid syringoma (MCS) is one of the rarest subtypes, and as such, still poorly understood. It lacks distinctive clinical features, often delaying initial diagnosis and therapeutic management.
A current case and the available literature are reviewed to determine the overall clinical course of the MCS and the potential role of adjuvant therapy.
A case of MCS was studied by light microscope, immunohistochemistry, and electron microscopy. The clinical data of this case and of other reported cases are summarized and compared.
This tumor recurred locally after initial local excision. Subsequent re-excision and radiation therapy rendered the patient without evidence of disease. This case study and the literature review of the 20 reported cases indicate that MCS is highly recurrent with tendency toward metastasis.
MCS appears to behave in an aggressive manner. An initial treatment modality is aggressive surgery. Adjuvant radiation therapy with or without chemotherapy should be tried in future cases.
恶性汗腺肿瘤是极其罕见的肿瘤。恶性软骨样汗管瘤（MCS）是最罕见的亚型之一，因此，目前对其了解仍很少。它缺乏独特的临床特征，常常延误初始诊断和治疗管理。
回顾1例当前病例及现有文献，以确定MCS的整体临床病程及辅助治疗的潜在作用。
通过光学显微镜、免疫组织化学和电子显微镜对1例MCS病例进行研究。总结并比较该病例及其他报告病例的临床资料。
该肿瘤在初次局部切除后局部复发。随后再次切除并进行放射治疗，使患者无疾病证据。本病例研究及对20例报告病例的文献回顾表明，MCS具有高复发性且有转移倾向。
MCS似乎具有侵袭性。初始治疗方式为积极手术。未来病例应尝试辅助放疗，可联合或不联合化疗。
