Wada D R, Stanski D R, Ebling W F
Stanford University, Department of Anesthesia, CA 94305-5117, USA.
Comput Methods Programs Biomed. 1995 Apr;46(3):245-55. doi: 10.1016/0169-2607(95)01624-3.
Since many intravenous anesthetic drugs alter blood flows, physiologically-based pharmacokinetic models describing drug disposition may be time-varying. Using the commercially available programming software MATLAB, a platform to simulate time-varying physiological pharmacokinetic models was developed. The platform is based upon a library of pharmacokinetic blocks which mimic physiological structure. The blocks can be linked together flexibly to form models for different drugs. Because of MATLAB's additional numerical capabilities (e.g. non-linear optimization), the platform provides a complete graphical microcomputer-based tool for physiologic pharmacokinetic modeling.
