Kindred B, Corley R B
Eur J Immunol. 1978 Jan;8(1):67-71. doi: 10.1002/eji.1830080114.
BALB/c nude mice have been injected with 10(6) congenic thymus cells, a number which allows some, but not all mice to respond to any particular T-dependent antigen. These mice have been tested for their ability to respond to three bacteriophages, T4, T7 and phiX, sheep and horse erythrocytes, and alloantigens of C3H and C57BL/6 mice. The number of mice able to respond to each of these antigens was of the same order of magnitude. Sheep and horse erythrocytes showed cross-reactivity at the T cell level, i.e. the responses to these two antigens were not independent. The same was observed for C3H and C57BL/6. Otherwise, the responses were independent showing that the antigens are recognize by different populations of specific helper T cells.
已向BALB/c裸鼠注射了10⁶个同基因胸腺细胞，这个数量能使部分（而非全部）小鼠对任何特定的T细胞依赖性抗原产生反应。对这些小鼠针对三种噬菌体（T4、T7和phiX）、绵羊和马红细胞以及C3H和C57BL/6小鼠的同种异体抗原的反应能力进行了测试。能够对这些抗原中的每一种产生反应的小鼠数量处于相同的数量级。绵羊和马红细胞在T细胞水平上表现出交叉反应性，即对这两种抗原的反应并非相互独立。C3H和C57BL/6的情况也是如此。否则，这些反应是独立的，表明这些抗原是由不同群体的特异性辅助性T细胞识别的。
