Landin-Wilhelmsen K, Wilhelmsen L, Wilske J, Lappas G, Rosén T, Lindstedt G, Lundberg P A, Bengtsson B A
Department of Medicine, Göteborg University, Sweden.
Eur J Clin Nutr. 1995 Jun;49(6):400-7.
To determine serum 25-hydroxyvitamin D3 [25(OH)D3] and its 1-hydroxylated metabolite [1,25(OH)2D3] and relate them to anthropometric data, life-style habits, blood pressure and selected biochemical analytes.
Random population samples of men and women.
Göteborg, Sweden, population size 450,000 inhabitants. The study was performed within the framework of the WHO MONICA Project.
2000 randomly selected subjects were invited to the main MONICA screening. Out of those 1421 (71%) participated. Fifty individuals in each of four age-groups, 25-64 years, were selected at random for the present analyses (184 men and 198 women).
The concentration of 25(OH)D3 was similar in both sexes whereas 1,25(OH)2D3 concentration was higher in women than in men (P = 0.01). 25(OH)D3 correlated positively to sun exposure, physical activity and negatively to intact parathyroid hormone (PTH) in both sexes, and also negatively to blood pressure in men. The remaining significant relationship for 25(OH)D3, when age and sun exposure were taken into account in multivariate analyses, was a negative correlation to intact PTH in both sexes. 1,25(OH)2D3 correlated positively to intact PTH in both men and women, negatively to height in men, positively to fibrinogen in men and positively to psychological stress and osteocalcin in women. When all variables were included in multivariate analyses 1,25(OH)2D3 concentration correlated negatively to age and positively to intact PTH and osteocalcin in both sexes together.
Sunlight was the only external factor that influenced 25(OH)D3 concentration whereas 1,25(OH)2D3 was unaffected by sun exposure. 1,25(OH)2D3 was not related to environmental or life style factors but declined by age and correlated positively to intact PTH and osteocalcin.
Grants from the Swedish Medical Research Council and the Swedish Heart and Lung Foundation.
测定血清25-羟基维生素D3 [25(OH)D3] 及其1-羟化代谢产物 [1,25(OH)2D3]，并将其与人体测量数据、生活方式习惯、血压及选定的生化分析物相关联。
男性和女性的随机人群样本。
瑞典哥德堡，人口规模为45万居民。该研究在世卫组织莫尼卡项目框架内进行。
2000名随机选取的研究对象被邀请参加莫尼卡主要筛查。其中1421人（71%）参与。从25至64岁的四个年龄组中各随机选取50人进行本次分析（184名男性和198名女性）。
25(OH)D3浓度在两性中相似，而1,25(OH)2D3浓度女性高于男性（P = 0.01）。25(OH)D3在两性中均与阳光照射、身体活动呈正相关，与完整甲状旁腺激素（PTH）呈负相关，在男性中还与血压呈负相关。在多变量分析中考虑年龄和阳光照射后，25(OH)D3其余的显著关系是与两性的完整PTH呈负相关。1,25(OH)2D3在男性和女性中均与完整PTH呈正相关，在男性中与身高呈负相关，在男性中与纤维蛋白原呈正相关，在女性中与心理压力和骨钙素呈正相关。当所有变量纳入多变量分析时，1,25(OH)2D3浓度在两性中均与年龄呈负相关，与完整PTH和骨钙素呈正相关。
阳光是影响25(OH)D3浓度的唯一外部因素，而1,25(OH)2D3不受阳光照射影响。1,25(OH)2D3与环境或生活方式因素无关，但随年龄下降，并与完整PTH和骨钙素呈正相关。
瑞典医学研究委员会和瑞典心肺基金会提供的资助。
