[Acute toxicity of liver targeting mitoxantrone-nanospheres].

The experimental result of acute toxicity of liver targeted drug delivery system-mitoxantrone-polybutylcyanoacrylate-nanospheres (DHAQ-PBCA-NS) in mice is reported. The results showed that the acute toxicity of DHAQ-PBCA-NS i.v. in mice was lower than that of DHAQ (LD50 = 16.9 +/- 3.9 mg/kg). The cells of the heart, liver, spleen, kidney and lung had no pathological change. It has been shown that mitoxantrone-nanospheres have some value of application.