Zhang Z, Liao G, Hou S, Bai S, Zhang X
Hua Xi Yi Ke Da Xue Xue Bao. 1993 Dec;24(4):381-4.
This paper reports the result of an experiment on the anticarcinogenic effect of liver targeted drug delivery system-mitoxantrone-polybutylcyanoacrylate-nanospheres (DHAQ-PBCA-NS) by using a model of heterotopic and orthotopic transplantation of human hepatocellular carcinoma (HCC) in nude mice. No significant difference was noted between the anti-HCC effects of mitoxantrone and dexerubicin, but the anti-orthotopic transplanting HCC effect of mitoxantrone-nanospheres was obviously higher than that of mitoxantrone and dexerubicin by comparison of tumor inhibition rates and proliferating cell nuclear antigen (PCNA). The result showed the applicability of mitoxantrone-nanospheres.
本文报道了利用人肝细胞癌（HCC）裸鼠异位和原位移植模型，对肝靶向给药系统——米托蒽醌-聚氰基丙烯酸正丁酯纳米球（DHAQ-PBCA-NS）的抗癌作用进行实验的结果。米托蒽醌和多柔比星的抗肝癌作用之间未观察到显著差异，但通过肿瘤抑制率和增殖细胞核抗原（PCNA）比较，米托蒽醌纳米球的抗原位移植肝癌作用明显高于米托蒽醌和多柔比星。结果表明米托蒽醌纳米球具有适用性。
