Ishizuka M, Kawatsu M, Yamashita T, Ueno M, Takeuchi T
Institute for Chemotherapy, Microbial Chemistry Research Foundation, Shizuoka, Japan.
Int J Immunopharmacol. 1995 Feb;17(2):133-39. doi: 10.1016/0192-0561(94)00086-4.
In order to develop a new class of low molecular weight immunomodulators for the treatment of incurable diseases involving cancer, hematologic diseases and inflammation, we have sought cytokine inducers and inhibitors of cell adhesion to the extracellular matrix among the low molecular compounds produced by microorganisms. Cytogenin, cytoblastin (a monokine inducer), conagenin (a lymphokine inducer) and delaminomycins and IC-101 (inhibitors of cell adhesion to extracellular matrices) have been recently found in our institute. In this report, we describe the principles of screening and structures, and discuss their biological activities.
为开发一类新型低分子量免疫调节剂用于治疗包括癌症、血液系统疾病和炎症在内的不治之症，我们在微生物产生的低分子化合物中寻找细胞因子诱导剂和细胞与细胞外基质粘附的抑制剂。细胞生成素、成细胞素（一种单核因子诱导剂）、促胶原蛋白（一种淋巴因子诱导剂）以及脱层霉素和IC-101（细胞与细胞外基质粘附的抑制剂）最近已在我们研究所被发现。在本报告中，我们描述了筛选原理和结构，并讨论了它们的生物学活性。
