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Delaminomycins, novel nonpeptide extracellular matrix receptor antagonist and a new class of potent immunomodulator. II. Physico-chemical properties and structure elucidation of delaminomycin A.

作者信息

Ueno M, Someno T, Sawa R, Iinuma H, Naganawa H, Ishizuka M, Takeuchi T

机构信息

Institute for Chemotherapy, Microbial Chemistry Research Foundation, Shizuoka, Japan.

出版信息

J Antibiot (Tokyo). 1993 Jun;46(6):979-84. doi: 10.7164/antibiotics.46.979.

DOI:10.7164/antibiotics.46.979
PMID:8393852
Abstract

Delaminomycins, novel extracellular matrix receptor antagonists, have been isolated from a culture broth of Streptomyces albulus MJ202-72F3. The structure of delaminomycin A was determined to be 3-[[2-[(3E,5E)-2,8-dihydroxy-7-methyl-3,5-decadienyl]- 1,6,8- trimethyl-1,2,4a,5,6,7,8,8a-octahydro-1-naphthyl]carbonyl]-5- hydroxypyrrolidine-2,4-dione by analyses of spectral properties and chemical studies.

摘要

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