Pirsig W, Bean J K, Lenders H, Verwoerd C D, Verwoerd-Verhoef H L
Department of Otorhinolaryngology, Universitäts-HNO-Klinik, Ulm, Germany.
Int J Pediatr Otorhinolaryngol. 1995 May;32(2):171-81. doi: 10.1016/0165-5876(94)01121-d.
For the first time it was observed in a boy that a xenogenic implant of demineralized bovine bone matrix, enfolded in a pedicled flap of autogenic ear perichondrium, was transformed into autogenic cartilage. This new cartilage could be adequately used as a graft to bridge the cartilaginous defect of a nasal septum perforation. The defect was successfully closed by a technique employing four bipedicled mucosal advancement flaps of the septum and the nasal floor. The result of this pilot study, which is based on experiments in growing rabbits, appears to open the possibility to create de novo young and growing autogenic cartilage of substantial quantity in children, without the loss of the cartilage present.
首次在一名男孩身上观察到，包裹在自体耳软骨膜带蒂皮瓣中的脱矿牛骨基质异种移植物转化为自体软骨。这种新软骨可充分用作移植材料，以修复鼻中隔穿孔的软骨缺损。采用鼻中隔和鼻底的四个双蒂黏膜推进皮瓣技术，成功闭合了缺损。这项基于对生长中的兔子进行实验的初步研究结果，似乎为在儿童身上大量生成全新的年轻且生长中的自体软骨开辟了可能性，同时不会损失现有的软骨。
