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人类外周血单个核白细胞对可见光的敏感性。

Sensitivity of human peripheral blood mononuclear leukocytes to visible light.

作者信息

Finocchiaro L M, Polack E, Nahmod V E, Glikin G C

机构信息

Laboratorio de Sustancias Vasoactivas, Instituto de Investigaciones Médicas, Universidad de Buenos Aires, Argentina.

出版信息

Life Sci. 1995;57(11):1097-110. doi: 10.1016/0024-3205(95)02055-n.

DOI:10.1016/0024-3205(95)02055-n
PMID:7658917
Abstract

Overnight light exposure of cultured human peripheral blood mononuclear leukocytes [PBML], significantly increased basal [3H]thymidine incorporation and upon stimulation with phytohemagglutinin [PHA]. Melatonin (10(-9) to 10(-5) M) enhanced the light-induced increase of [3H]thymidine incorporation, while serotonin (10(-9) to 10(-7) M) stimulated [3H]thymidine incorporation in the dark. The wavelengths responsible of this effect were restricted to the blue-green zone of the spectrum. The stimulatory effect of visible light on PHA-induced DNA replication had a circannual rhythm, being maximal during winter. In winter, white light also reduced melatonin and serotonin binding to PBML membranes and switched the PBML indole metabolism towards serotonin and 5-hydroxy-indole-acetic acid [HIAA] synthesis, with a concomitant decrease of melatonin production.

摘要

培养的人外周血单个核白细胞(PBML)过夜暴露于光照下,显著增加了基础[3H]胸腺嘧啶核苷掺入量,并且在用植物血凝素(PHA)刺激后也是如此。褪黑素(10^(-9)至10^(-5)M)增强了光照诱导的[3H]胸腺嘧啶核苷掺入量的增加,而血清素(10^(-9)至10^(-7)M)在黑暗中刺激[3H]胸腺嘧啶核苷掺入。造成这种效应的波长局限于光谱的蓝绿色区域。可见光对PHA诱导的DNA复制的刺激作用具有年节律,在冬季最大。在冬季,白光还减少了褪黑素和血清素与PBML膜的结合,并使PBML吲哚代谢转向血清素和5-羟基吲哚乙酸(HIAA)合成,同时褪黑素生成减少。

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