Yamamoto M, Hibi H, Katsuno S, Miyake K
Department of Urology, Nagoya University School of Medicine, Japan.
Nagoya J Med Sci. 1995 Mar;58(1-2):41-5.
Leukocytospermia has been associated with notable adverse effects on semen parameters and sperm function. The present study was undertaken to identify men with leukocytospermia and prostatitis in an infertility population and assess the effects of various treatments. One million white blood cells (WBC)/ml semen was defined as leukocytospermia. An expressed prostatic fluid was analyzed for the presence of white blood cells. The presence of more than 10 WBCs/high power field on expressed prostatic secretion was needed for the diagnosis of prostatitis. Those men who had more than one million WBCs in their semen and more than 10 WBCs/high power field on expressed prostatic secretion were enrolled in this study. Of two hundred sixty-three men screened for the presence of leukocytospermia and prostatitis, forty-eight men met both criteria. They were blindly and randomly assigned to one of three groups. Group 1 received no treatment. Group 2 were treated with trimethoprim 80 mg-sulfamethoxazole 400 mg (TMP-SMX) orally twice per day for one month. Group 3 were treated not only with the same antibiotic regimen as group 2 but also were instructed to ejaculate frequently (at least once every three days) for one month. Significant resolution of leukocytospermia occurred in the order of patient groups 3 > 2 > 1 at one month. The resolution rate of leukocytospermia of each group was 76% in group 3, 56% in group 2 and 6.7% in group 1. The rates in groups 2 and 3 were significantly higher than that in group 1 (p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
白细胞精子症已被证实对精液参数和精子功能有显著不良影响。本研究旨在识别不育人群中患有白细胞精子症和前列腺炎的男性，并评估各种治疗方法的效果。每毫升精液中白细胞（WBC）数量达到100万个被定义为白细胞精子症。对前列腺液进行白细胞检测。诊断前列腺炎需要前列腺分泌液中每高倍视野白细胞超过10个。精液中白细胞超过100万个且前列腺分泌液中每高倍视野白细胞超过10个的男性被纳入本研究。在263名接受白细胞精子症和前列腺炎筛查的男性中，48名符合这两个标准。他们被随机盲法分为三组。第一组不接受治疗。第二组每天口服两次80毫克甲氧苄啶 - 400毫克磺胺甲恶唑（TMP - SMX），持续一个月。第三组不仅接受与第二组相同的抗生素治疗方案，还被要求频繁射精（至少每三天一次），持续一个月。一个月时，白细胞精子症的显著缓解情况按患者组顺序为3>2>1。第三组白细胞精子症缓解率为76%，第二组为56%，第一组为6.7%。第二组和第三组的缓解率显著高于第一组（p<0.05）。（摘要截断于250字）
