Erel C T, Sentürk L M, Demir F, Irez T, Ertüngealp E
Istanbul University, Cerrahpasa School of Medicine, Department of Obstetrics and Gynecology, Turkey.
Int J Fertil Womens Med. 1997 May-Jun;42(3):206-10.
In this prospective study, we aimed to determine the efficacy of doxycycline and doxycycline plus ceftriaxone for the treatment of asymptomatic men with leukocytospermia.
Seventy men were included in this randomized and placebo-controlled study. White blood cell (WBC) concentrations were determined by peroxidase assay during the routine semen analysis. Twenty-four of 70 men with leukocytospermia were randomized as control group and administered placebo (group I), 25 received doxycyline alone (group II), and 21, doxycycline plus ceftriaxone (group III). Doxycycline, 100 mg, was given twice a day for ten days and ceftriaxone, 1 g, in two doses for only one day. After the treatment, semen analyses were repeated.
After the treatment there was a significant decrease in WBC counts in groups II and III when compared with group I (P < .05). Both antibiotic regimens were found to be equally effective. However, the time needed for resolution of leukocytospermia (approximately 4 weeks) was similar between the control and treatment groups.
Although both antibiotic regimens significantly, and equally, improved the white blood cell counts in men with leukocytospermia, they failed to treat the leukocytospermia, i.e., to bring the count below the limit of one million WBC/mL. Therefore, it is doubtful that antibiotic therapy should be recommended for asymptomatic men with leukocytospermia.
在这项前瞻性研究中，我们旨在确定多西环素以及多西环素联合头孢曲松治疗无症状白细胞精子症男性的疗效。
70名男性纳入了这项随机安慰剂对照研究。在常规精液分析期间通过过氧化物酶测定法确定白细胞（WBC）浓度。70名白细胞精子症男性中的24名被随机分为对照组并给予安慰剂（I组），25名仅接受多西环素治疗（II组），21名接受多西环素联合头孢曲松治疗（III组）。多西环素100毫克，每日两次，服用十天，头孢曲松1克，分两剂仅服用一天。治疗后，重复进行精液分析。
治疗后，与I组相比，II组和III组的白细胞计数显著降低（P <.05）。发现两种抗生素治疗方案同样有效。然而，对照组和治疗组之间解决白细胞精子症所需的时间（约4周）相似。
虽然两种抗生素治疗方案均显著且同等程度地改善了白细胞精子症男性的白细胞计数，但它们未能治愈白细胞精子症，即将计数降至每毫升100万个白细胞的限度以下。因此，对于无症状白细胞精子症男性是否应推荐抗生素治疗值得怀疑。
