Efficacy of treatment and recurrence rate of leukocytospermia in infertile men with prostatitis.

OBJECTIVE

To identify men with leukocytospermia and prostatitis in an infertility practice and evaluate the effect of various treatments and recurrence rates after treatment.

DESIGN

A prospective randomized trial of men with leukocytospermia.

SETTING

Academic tertiary infertility clinic.

PATIENTS

One hundred two men with leukocytosperimia identified on smear of semen using Bryan-Leishman stain and in expressed prostatic secretion.

INTERVENTIONS

Treatment groups were no treatment group; antibiotic treatment alone group; frequent ejaculation alone group; and antibiotic treatment with frequent ejaculation group.

MAIN OUTCOME MEASURE

Resolution of leukocytospermia on semen smear.

RESULTS

Significant resolution of leukocytospermia occurred in all treatment groups at 1 month compared with no treatment. The resolution was sustained at 2 and 3 months only in those who took antibiotics and frequently ejaculated.

CONCLUSIONS

Antibiotic treatment, frequent ejaculation, and antibiotic treatment with frequent ejaculation effectively treat leukocytospermia immediately after the treatment phase. However, only antibiotic treatment coupled with frequent ejaculation is effective 3 months after treatment.