Jobert M, Poiseau E, Jähnig P, Gaillard P, Schulz H
PAREXEL, Independent Pharmaceutical Research Organization, Berlin, Germany.
Neuropsychobiology. 1995;31(4):204-9. doi: 10.1159/000119195.
The influence of the benzodiazepine hypnotic lormetazepam (1 mg) and the cyclopyrrolone hypnotic zopiclone (7.5 mg) on heart rate activity was studied in 16 elderly insomniacs in a placebo-controlled, randomised, 3-fold crossover trial. After digital preprocessing of the ECG, QRS complexes were automatically recognised by a detection technique based on adaptative thresholds. Both R-R periodicity and heart rate variability were analysed as a function of sleep stages and time of night. Under placebo, heart rate decreased significantly from the first to the second half of the night. The relationship between sleep stages and heart rate remained constant under both hypnotics. Although the two substances significantly modified the distribution of sleep stages, no relevant changes in ECG activity were observed when the proportion of the different sleep stages was taken into consideration.
在一项安慰剂对照、随机、三交叉试验中，对16名老年失眠患者研究了苯二氮䓬类催眠药氯美扎酮（1毫克）和环吡咯酮类催眠药佐匹克隆（7.5毫克）对心率活动的影响。在对心电图进行数字预处理后，基于自适应阈值的检测技术自动识别QRS复合波。将R-R周期和心率变异性作为睡眠阶段和夜间时间的函数进行分析。在安慰剂作用下，心率从夜间前半段到后半段显著下降。两种催眠药作用下，睡眠阶段与心率之间的关系保持不变。尽管这两种药物显著改变了睡眠阶段的分布，但考虑到不同睡眠阶段的比例时，未观察到心电图活动的相关变化。
