实验性脊髓损伤中的脂质过氧化反应。银杏叶、促甲状腺激素释放激素与甲基强的松龙治疗效果的比较。

Lipid peroxidation in experimental spinal cord injury. Comparison of treatment with Ginkgo biloba, TRH and methylprednisolone.

作者信息

Koç R K, Akdemir H, Kurtsoy A, Paşaoğlu H, Kavuncu I, Paşaoğlu A, Karaküçük I

机构信息

Department of Neurosurgery, Erciyes University, School of Medicine, Kayseri, Turkey.

出版信息

Res Exp Med (Berl). 1995;195(2):117-23. doi: 10.1007/BF02576781.

DOI:10.1007/BF02576781

PMID:7659833

Abstract

Ischaemia-induced lipid peroxidation is one of the most important factors producing tissue damage in spinal cord injury. In our study, the protective effects of Ginkgo biloba, thyroid releasing hormone (TRH) and methylprednisolone (MP) on compression injury of the rat spinal cord were investigated. For this study 45 rats in four groups, including control, MP, TRH and Gingko biloba, were used to determine the formation of malondialdehyde (MDA). All the animals were made paraplegic by the application clip method of Rivlin and Tator. Rats were divided randomly and blindly to one of four treatment groups (ten animals in each). MP and Ginkgo biloba treatments significantly decreased MDA levels (F = 54.138, P < 0.01). These results suggest that MP and Ginkgo biloba may have a protective effect against ischaemic spinal cord injury by the antioxidant effect.

摘要

缺血诱导的脂质过氧化是脊髓损伤中导致组织损伤的最重要因素之一。在我们的研究中，研究了银杏叶、促甲状腺激素释放激素（TRH）和甲基强的松龙（MP）对大鼠脊髓压迫性损伤的保护作用。在本研究中，使用45只大鼠分为四组，包括对照组、MP组、TRH组和银杏叶组，以测定丙二醛（MDA）的形成。所有动物均通过Rivlin和Tator的夹闭法造成截瘫。将大鼠随机且盲法分为四个治疗组之一（每组十只动物）。MP和银杏叶治疗显著降低了MDA水平（F = 54.138，P < 0.01）。这些结果表明，MP和银杏叶可能通过抗氧化作用对缺血性脊髓损伤具有保护作用。