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新西兰哮喘发病率大幅下降,哮喘死亡率持续降低:从中吸取了哪些经验教训?

Major reduction in asthma morbidity and continued reduction in asthma mortality in New Zealand: what lessons have been learned?

作者信息

Garrett J, Kolbe J, Richards G, Whitlock T, Rea H

机构信息

Department of Respiratory Medicine, Green Lane Hospital, Auckland, New Zealand.

出版信息

Thorax. 1995 Mar;50(3):303-11. doi: 10.1136/thx.50.3.303.

Abstract

Increasing financial barriers to primary health care against a background of social and economic decline are likely to have contributed to asthma morbidity and mortality in New Zealand. Although there would not have been a sufficient increase in asthma prevalence to have accounted for the threefold increase in mortality rates, whether or not there was an increase in asthma severity in the late 1970s remains open to debate. Misuse or poor use of newly available and potent bronchodilator medications by those with the most severe asthma may simply have contributed to further delays in obtaining appropriate care and therefore to an increase in frequency of severe attacks in the community. Despite substantial increases in the use of bronchodilator therapy in New Zealand, there was no immediate improvement in indices of either asthma morbidity or mortality. The initial reduction in mortality rates in the 1980s happened at a time when first admissions for asthma were still increasing and seems to be best explained by an improvement in utilisation of hospital services (which were free until 1992) rather than a reduction in asthma severity. However, the recent reductions in all measures of asthma morbidity and further reduction in asthma mortality since 1989 does now suggest a reduction in asthma severity and would be best explained by the substantial increase in medium and high dose inhaled corticosteroid use, and to the endorsement of the current management strategies for asthma which are being promoted internationally and which were given considerable publicity in New Zealand in 1989 and 1990. Whilst sales of inhaled beta agonists were higher in 1991 than 1989, this may not reflect their pattern of use by individual patients since the need for an increase in inhaled beta agonist treatment has been accepted as indicating a lack of control and the need for either starting or increasing the dose of inhaled steroid treatment.

摘要

在社会经济衰退的背景下,初级卫生保健方面不断增加的经济障碍可能导致了新西兰哮喘的发病率和死亡率上升。尽管哮喘患病率的增加幅度不足以解释死亡率的三倍增长,但20世纪70年代末哮喘严重程度是否增加仍存在争议。哮喘最严重的患者对新出现的强效支气管扩张剂药物的滥用或使用不当,可能只是导致获得适当治疗的进一步延迟,从而导致社区中严重发作频率增加。尽管新西兰支气管扩张剂治疗的使用大幅增加,但哮喘发病率或死亡率指标并未立即得到改善。20世纪80年代死亡率的最初下降发生在哮喘首次入院人数仍在增加的时候,似乎最好的解释是医院服务利用率的提高(1992年之前医院服务是免费的),而不是哮喘严重程度的降低。然而,自1989年以来哮喘发病率所有指标的近期下降以及哮喘死亡率的进一步下降,现在确实表明哮喘严重程度有所降低,最好的解释是中高剂量吸入性糖皮质激素使用的大幅增加,以及对目前国际上推广的哮喘管理策略的认可,这些策略在1989年和1990年在新西兰得到了广泛宣传。虽然1991年吸入性β受体激动剂的销量高于1989年,但这可能无法反映个体患者的使用模式,因为吸入性β受体激动剂治疗需求的增加已被认为表明控制不佳,需要开始或增加吸入性类固醇治疗的剂量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f65a/1021198/6f08936ad8cb/thorax00308-0099-a.jpg

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