针对不同细胞表面决定簇的抗体的协同细胞毒性作用。
Synergistic cytotoxic effects of antibodies directed against different cell surface determinants.
作者信息
Elliott E V, Pindar A, Stevenson F K, Stevenson G T
出版信息
Immunology. 1978 Mar;34(3):405-9.
Three antibody populations were raised in rabbits against surface antigens on guinea-pig L2C leukaemic lymphocytes: against idiotypic determinants on the lambda chain of the surface immunoglobulin, against C region determinants on the lambda chain, and against the surface antigens recognized by conventional anti-lymphocyte sera. Complement and K-cell cytotoxicities effected by the antibodies on L2C cells were studied in vitro. In both cytotoxic systems mixtures of the antibodies revealed synergy, in that the titres of the mixtures exceeded predicted additive titres of their components. The synergy was greater when the mixed antibodies were directed to determinants on the same molecule rather than to determinants on different molecules.
针对豚鼠L2C白血病淋巴细胞表面抗原，在兔体内产生了三种抗体群体：针对表面免疫球蛋白λ链上的独特型决定簇、针对λ链上的C区决定簇以及针对常规抗淋巴细胞血清所识别的表面抗原。体外研究了这些抗体对L2C细胞产生的补体和K细胞细胞毒性。在这两种细胞毒性系统中，抗体混合物均显示出协同作用，即混合物的效价超过其各组分预期相加效价。当混合抗体针对同一分子上的决定簇而非不同分子上的决定簇时，协同作用更强。
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