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豚鼠中的一种γ本斯-琼斯蛋白。

A gamma Bence-Jones protein in guinea pigs.

作者信息

Stevenson F K, Mole L E, Raymont C M, Stevenson G T

出版信息

Biochem J. 1975 Dec;151(3):751-3. doi: 10.1042/bj1510751.

DOI:10.1042/bj1510751
PMID:814896
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1172425/
Abstract
  1. The L2C lymphocytic leukaemia in strain-2 guinea pigs is accompanied by a protein in the urine resembling a homogenous immunoglobulin light chain. 2. The amino acid sequence over the first 20 residues demonstrates a close analogy with a human gamma chain of V region subgroup IV. 3. The protein is apparently synthesized by the leukaemic cells and thus represents a monoclonal light chain, i.e. a Bence-Jones protein.
摘要
  1. 2号品系豚鼠中的L2C淋巴细胞白血病伴有尿液中的一种蛋白质,类似于均质免疫球蛋白轻链。2. 前20个残基的氨基酸序列与人类V区亚群IV的γ链有密切的相似性。3. 该蛋白质显然是由白血病细胞合成的,因此代表一种单克隆轻链,即本斯·琼斯蛋白。
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e2d/1172425/38a4b4b86c87/biochemj00547-0306-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e2d/1172425/38a4b4b86c87/biochemj00547-0306-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e2d/1172425/38a4b4b86c87/biochemj00547-0306-a.jpg

相似文献

1
A gamma Bence-Jones protein in guinea pigs.豚鼠中的一种γ本斯-琼斯蛋白。
Biochem J. 1975 Dec;151(3):751-3. doi: 10.1042/bj1510751.
2
Primary structure of the variable region of a human lambda VI light chain: Bence Jones protein SUT.人λVI轻链可变区的一级结构:本斯·琼斯蛋白SUT
J Immunol. 1983 Nov;131(5):2490-3.
3
[A case of B cell chronic lymphocytic leukemia with IgG-lambda serum M-protein and lambda Bence Jones proteinuria].一例伴有IgG-λ血清M蛋白和λ本-周蛋白尿的B细胞慢性淋巴细胞白血病
Nihon Naika Gakkai Zasshi. 1985 Aug;74(8):1133-8.
4
The primary structure of a monoclonal human lambda-type immunoglobulin L-chain of subgroup II (Bence-Jones protein NEI).
Eur J Biochem. 1972 Mar 15;26(1):10-32. doi: 10.1111/j.1432-1033.1972.tb01734.x.
5
Bence Jones proteins and light chains of immunoglobulins. Preferential association of the V lambda VI subgroup of human light chains with amyloidosis AL (lambda).本斯·琼斯蛋白与免疫球蛋白轻链。人轻链VλVI亚组与AL型(λ)淀粉样变性的优先关联。
J Clin Invest. 1982 Aug;70(2):453-60. doi: 10.1172/jci110635.
6
[Principle of antibody structure. The primary structure of a monoclonal kappa I-type immunoglobulin L-chain aggregate forms, (Bence Jones protein Bi). I. Purification, and characterization of the protein].
Hoppe Seylers Z Physiol Chem. 1972 Aug;353(8):1259-72.
7
Amino acid sequence of an amyloidogenic Bence Jones protein in myeloma-associated systemic amyloidosis.骨髓瘤相关性系统性淀粉样变性中一种淀粉样变性本-周蛋白的氨基酸序列。
FEBS Lett. 1985 Jun 3;185(1):139-41. doi: 10.1016/0014-5793(85)80757-2.
8
[The primary structure of a monoclonic immunoglobulin-L-chain of subgroup IV of the kappa type (Bence-Jones protein Len.)].[κ型IV亚组单克隆免疫球蛋白轻链(本斯·琼斯蛋白Len.)的一级结构]
Hoppe Seylers Z Physiol Chem. 1975 May;356(5):507-57.
9
[Structural rule of antibodies. Complete primary structure of a monoclonal immunoglobin L chain of the lambda type, subgroup II (Bence Jones protein VIL)].[抗体的结构规则。λ型II亚组单克隆免疫球蛋白L链(本斯·琼斯蛋白VIL)的完整一级结构]
Hoppe Seylers Z Physiol Chem. 1971 Jun;352(6):859-77.
10
Association of human lambda light chain V/J/C segments: serologic analysis and primary structure of the lambda VI Bence Jones protein THO.人λ轻链V/J/C区段的关联:λVI本斯·琼斯蛋白THO的血清学分析及一级结构
J Immunol. 1986 Jan;136(2):716-9.

引用本文的文献

1
Antigenic modulation of lymphocytic surface immunoglobulin yielding resistance to complement-mediated lysis. I. Characterization with syngeneic and xenogeneic complements.淋巴细胞表面免疫球蛋白的抗原调制产生对补体介导裂解的抗性。I. 同基因和异种补体的特性研究
Immunology. 1981 Jan;42(1):7-12.
2
Some effects on leukaemic B lymphocytes of antibodies to defined regions of their surface immunoglobulin.针对白血病B淋巴细胞表面免疫球蛋白特定区域的抗体对其产生的某些影响。
Immunology. 1977 Apr;32(4):549-57.
3
Further studies of immunoglobulin synthesis by guinea pig leukaemic lymphocytes.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
CONTRIBUTION OF GAMMA-GLOBULIN SUBUNITS TO ELECTROPHORETIC HETEROGENEITY: IDENTIFICATION OF A DISTINCTIVE GROUP OF 6.6S GAMMA-MYELOMA PROTEINS.γ球蛋白亚基对电泳异质性的作用:一类独特的6.6Sγ骨髓瘤蛋白的鉴定
Immunochemistry. 1964 Jun;1:121-31. doi: 10.1016/0019-2791(64)90076-x.
3
PROTEIN-PROTEIN INTERACTIONS AMONG L POLYPEPTIDE CHAINS OF BENCE-JONES PROTEINS AND HUMAN GAMMA-GLOBULINS.本-周蛋白L多肽链与人类γ球蛋白之间的蛋白质-蛋白质相互作用
豚鼠白血病淋巴细胞免疫球蛋白合成的进一步研究。
Immunology. 1978 May;34(5):889-99.
4
Synergistic cytotoxic effects of antibodies directed against different cell surface determinants.针对不同细胞表面决定簇的抗体的协同细胞毒性作用。
Immunology. 1978 Mar;34(3):405-9.
5
Mediation of cytotoxic functions by classes and subclasses of sheep antibody reactive with cell surface immunoglobulin idiotypic and constant region determinants.与细胞表面免疫球蛋白独特型和恒定区决定簇反应的绵羊抗体类别和亚类对细胞毒性功能的介导作用。
Immunology. 1978 Feb;34(2):353-8.
J Exp Med. 1964 May 1;119(5):817-36. doi: 10.1084/jem.119.5.817.
4
MONOMER--DIMER FORMS OF BENCE JONES PROTEINS.本斯·琼斯蛋白的单体 - 二聚体形式
Nature. 1963 Oct 19;200:223-5. doi: 10.1038/200223b0.
5
Detection in normal urine of protein resembling Bence Jones protein.在正常尿液中检测到类似本斯·琼斯蛋白的蛋白质。
J Clin Invest. 1960 Jul;39(7):1192-200. doi: 10.1172/JCI104134.
6
Further studies of the phenol-sulfuric acid reagent for carbohydrates.碳水化合物的酚-硫酸试剂的进一步研究。
Biochim Biophys Acta. 1961 Apr 15;48:591-3. doi: 10.1016/0006-3002(61)90059-2.
7
The heat precipitation of Bence-Jones proteins. I. Optimum conditions.本斯-琼斯蛋白的热沉淀。I. 最佳条件。
Arch Biochem Biophys. 1959 Jul;83(1):115-30. doi: 10.1016/0003-9861(59)90016-5.
8
The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳测定分子量的可靠性。
J Biol Chem. 1969 Aug 25;244(16):4406-12.
9
One cell-one immunoglobulin. Origin of limited heterogeneity of myeloma proteins.一个细胞一种免疫球蛋白。骨髓瘤蛋白有限异质性的起源。
Biochem J. 1970 Jan;116(2):241-8. doi: 10.1042/bj1160241.
10
Relationships of two light chain immunoglobulins isolated from the same human source (low molecular weight immunoglobins).
Immunochemistry. 1965 Sep;2(3):207-18. doi: 10.1016/0019-2791(65)90002-9.